Novel enzymatic DNA produced from a text file achieves comparable immune responses as plasmid vaccine
Publications

Novel enzymatic DNA produced from a text file achieves comparable immune responses as plasmid vaccine

In this collaborative work with GE HealthCare (amplification by RCA), The Johns Hopkins University (sequencing and QC), and the University of Washington (vaccine administration in mice), researchers produced DNA using …
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Viral infection disrupts intestinal homeostasis via Sting-dependent NF-κB signaling in Drosophila
Publications

Viral infection disrupts intestinal homeostasis via Sting-dependent NF-κB signaling in Drosophila

This paper used SYNTAX-labeled fluorescent probes for RNA FISH to highlight how viral infection affects intestinal physiology and also revealed important interactions between immune pathways, gut physiology and aging in …
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DNA synthesis technologies to close the gene writing gap
Publications

DNA synthesis technologies to close the gene writing gap

Synthetic DNA is of increasing demand across many sectors of research and commercial activities. Engineering biology, therapy, data storage and nanotechnology are set for rapid developments if DNA can be …
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Assessment of enzymatically synthesized DNA for gene assembly
Publications

Assessment of enzymatically synthesized DNA for gene assembly

Phosphoramidite chemical DNA synthesis technology is utilized for creating de novo ssDNA building blocks and is widely used by commercial vendors. Recent advances in enzymatic DNA synthesis (EDS), including engineered …
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Multiplex enzymatic synthesis of DNA with single-base resolution
Publications

Multiplex enzymatic synthesis of DNA with single-base resolution

Enzymatic DNA synthesis (EDS) is a promising benchtop and user-friendly method of nucleic acid synthesis that, instead of solvents and phosphoramidites, uses mild aqueous conditions and enzymes. For applications such …
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