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General & Administration

Opportunity and Challenges

We are in the process of assembling a team of best-in-class, innovative and passionate individuals to join our Technical Support team. We want to leverage talents, skills, and expertise to achieve one goal: unlock the power of “DNA-write”. We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup company. Our SYNTAX ™ DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact as a product expert supporting a technology that will have a far-reaching impact across biological sciences.

The Role

DNA Script is actively searching for an accomplished Principal/Senior Scientist is responsible for effective and timely resolution of customer cases, including complaint investigations, case documentation, trending analysis and preparing reports, ensuring regulatory compliance and customer satisfaction. Will be responsible for providing technical and troubleshooting support for DNA Scripts Syntax System remotely by phone, email, and other remote support tools. Understands customers’ problems and recommends solutions to meet their needs. The ideal candidate has strong technical knowledge, expertise of primer based molecular workflows and automation system functionality, enjoys troubleshooting, has a problem-solving mindset and prior complaint handling experience.

Responsibilities:

Applications Support and Customer Engagement

  • Responsible for the timely case management of individual cases (Inquiries & Complaints) according to ISO Quality system requirements including creation, acceptance, classification, investigation, complete documentation, and resolution of cases.
  • Triage, monitor and follow up on customer communications using a customer relationship management database system.
  • Interface with internal teams when necessary, to escalate and resolve more complex cases.
  • Ensures, by collaboration and interfacing with stakeholders and global functions, that appropriate technical input and recommendations are communicated to Country Organizations ensuring that the customer is provided with a resolution or workaround in a timely manner.
  • Assist in the development of technical support tools and publications.
  • Accountable for providing information from cases to update product documentation.
  • Accountable for timely communication of quality related product information to cross functional key stakeholders, including Country Organizations.
  • Accountable for regular peer review of escalated cases and providing feedback and guidance to other case owners on expected documentation practices.
  • Oversees complaint databases to identify and report recurring issues to quality management and product development.
  • Performs case-related trending to understand the scope of an issue.
  • Performs regular reviews of case handling and documentation quality, analyzes feedback on customer satisfaction to permanently optimize processes to increase quality and efficiency standards with a focus on customer, compliance, and continuous improvement.

Technical Product Support

  • Writes and updates product user documentation.
  • Collaborate with internal experts by obtaining assistance on challenging cases and sharing product support information.
  • Support the delivery of fully integrated solutions, which may include peripherals, communications, operating systems and applications software.
  • Determine if customer complaint is best resolved via dispatch of field service and facilitate the handoff of issues to the field service team.
  • Provide advice to field service engineers to assist in the resolution of issues.
  • Provide voice of customer, user-oriented and service-related inputs to ongoing and new product development projects.
  • Update product support documentation including, but not limited to, User Guide and Frequently Asked Questions (FAQs). Author product information notifications as needed.
  • Identify product quality improvements using support data documented during customer and service interactions and communicate to stakeholders.

Preferred experience

Experience

  • Bachelor’s or Master’s degree within life science, engineering or related fields — e.g. Biomedical Engineering, Molecular Biology, Genomics, NextGen Sequencing, Analytical biochemistry, Biotechnology or similar.
  • 5+ years of work experience in a technical product support role, research & development role or similar position.
  • Proven experience interacting with researchers at all levels with life science and genomics applications.
  • Previous experience in training, oral presentations and technical writing/editing.

Ideal Candidate will have:

  • Detailed technical orientation, with robust analytical and organization skills, problem solving, troubleshooting capabilities and negotiation skills.
  • Prior experience using customer relationship management tools to document product support interactions with customers.
  • Worked with a field service organization supporting scientific instrumentation or medical devices.
  • Capability to precisely document issues, root cause analyses, troubleshooting experimentation and resolutions/repairs for complex scientific instrumentation.
  • Knowledge of varied regulatory requirements and quality practices, especially in complaint management (e.g., 21 CFR 820.198, ISO 13485)
  • Experience with Molecular Biology, Next Gen Sequencing, PCR, qPCR and related innovative technologies/application, including DNA synthesis experience, or utilization of synthetic oligos in biochemical applications.
  • Experience or expertise with Laboratory Automation solutions (eg. pipetting robots, electronics and linear actuators) and systems involving reagents, consumables and related system software.
  • Prior experience using customer relationship management tools to document product support interactions with customers.
  • Customer advocate, solutions-oriented mindset and business orientation.
  • Excellent written and verbal communication skills, presentation skills and technical writing.

Miscellaneous

  • The ideal candidate will be in Paris, France area- however remote candidates within the European Union (EU) will be considered
  • May require occasional travel to customer sites and corporate offices.

Recruitment process

  1. Phone interview with the hiring manager
  2. Day interview with manager, HR cofounders and the team
  3. References Check
  4. Timing: 2 – 3 weeks
Apply now

The Role:

We are looking for a full-time General Accountant to join our team. This accountant will be involved in all accounting topics related to our US subsidiary, including but not limited to: accounting, reporting, and transaction processing. This is an exciting opportunity for someone curious, driven, and willing, with a holistic view of accounting and to tackle new challenges as the company pursues its growth and development. If you are ready to make an impact at a mid stage life sciences company and looking for professional growth, you will thrive here at DNA Script.

Responsibilities:

  • Perform month-end, quarter-end and year-end closing duties, including preparing journal entries, variance reporting, reconciliations, and account analysis to ensure compliance with U.S. GAAP
  • Manage the accounting entry of our Accounts Payable
  • Reviewing invoices and entering them into Netsuite
  • All AP-related Journal Entries posting and schedules reconciliations
  • Responding to inquiries and requests from vendors and internal departments for any AP-related issues
  • Contribute to the implementation of our Accounts Receivable accounting system
  • Managing monitoring of Fixed Assets
  • Identify new Fixed Assets and disposals
  • Book D&A entries
  • Contribute to Inventory Management
  • Payroll accounting imports in NetSuite
  • Treasury Management
  • Processing payment batches
  • Performing banking reconciliation
  • Establishing basic cash projections
  • Ensure compliance with Company Purchasing Policy and PO Process
  • Working with our French Accounting Team, Global Finance Team, and our external accountant in the US to ensure alignment across the board
  • Ensure SOX compliance with accounting policies and procedures
  • Assist with year-end 1099 filings

Preferred Experience:

  • A Bachelor’s Degree in Finance, Accounting, Business, or something related
  • 4+ year of Accounts Payable or General Accounting Experience
  • Experience using NetSuite
  • 2+ years of work experience in a startup environment

Ideal Candidate will be:

  • Detail oriented with the ability to prioritize and identify potential issues
  • A self-starter that thrives in fast paced environment where change is constant
  • A strong communicator, comfortable communicating with all stakeholders in a professional manner

Recruitment process

  1. Phone interview with the hiring manager
  2. Day Interview at the office with the manager, cofounders, HR and the team
  3. References check
  4. Timing: 2-3 weeks
Apply now

The Mission

DNA Script is looking for an HR Assistant to join our HR team at our Paris office, who will assist the team with day-to-day operations and duties. This position reports to the VP, Corporate Operations.

Responsibilities

HR Administration:

  • Draft work contracts and amendments with the right template
  • Monitor probation periods for all employees
  • Keep the HRIS system, and more generally employee data, up to date
  • Plan onboarding of new employees, collect all necessary documents
  • Plan and track medical visits
  • Plan and track mandatory trainings
  • Prepare work permit and residence permit renewal requests for foreign employees
  • Prepare employment certificates
  • Publish job offers
  • Plan interviews with candidates

Office Management:

  • Preparation of meeting rooms
  • Filing of documents
  • Ordering office material, furniture, goodies
  • Update company’s website with employee pictures

Preferred experience

Experience and skills

Required

  • Excellent command of the English language
  • Bac +2/+3
  • At least 6 months of experience as an intern or apprentice
  • Ability to manage confidential and sensitive information with total discretion
  • Reliability, organizational skills and rigor
  • Versatility, curiosity, detail-oriented
  • Good command of the Office package & of Google Suite

Desirable

  • Experience with Payfit, Hibob, Trinet
  • Knowledge of SYNTEC collective agreement

Miscellaneous

  • Position based in Le Kremlin-Bicêtre (M7 Kremlin-Bicêtre or M7 Porte d’Italie)
  • Type of contract: Apprenticeship (ideally 3 days/week in the company)
  • Benefits include legal gratification, lunch vouchers (Swile) or canteen, 50% transportation fees reimbursement
  • Start date: ASAP
Apply now

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionately impatient people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.
We are seeking a strong software product owner to work with our dream team environment to deliver the best software solutions to our innovative and industry-leading products. This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.

Main Responsibilities:

  • Lead the scrum team as a software product owner within our agile software development process and provide direction to our high-performing development team
  • Create user stories from requirements and roadmap, refine them in cooperation with the scrum team, prioritize and manage the product feature backlog and development of product and features
  • Work with the scrum team throughout the development process to ensure team is executing on the highest value priorities
  • Maintain product backlog according to product roadmap, business value and to tune backlog prioritizations to balance business, customer, engineering priorities
  • Partner with Scrum Master/project manager and engineering leads to play an active role in mitigating impediments impacting successful team completion of release/sprint goals
  • Engage with marketing, research and development, quality assurance, customers, sales, service & support to effectively represent to the team the needs of stakeholders throughout the development process
  • Support process improvements to help establish new or mature existing processes
  • Participate in product strategy/roadmap planning

Experience:

  • Minimum of Bachelor’s degree in life sciences, computer science, engineering or a related field
  • 3+ years of experience working as a software product owner under scrum process
  • 5+ years of experience in agile software development, with preference given to candidates with experience in life sciences or related industry and/or previous experience as a developer
  • 3+ years of experience working in an Agile software development environment as part of a scrum team
  • Experience with Jira for work management and coordination with development
  • Prior experience developing e-Commerce solutions, a plus
  • Familiarity with NGS / qPCR technologies
  • Demonstrated experience interfacing directly with customers and/or marketing
  • Ability to collaborate with cross-functional teams
  • Excellent communication and collaboration skills

Miscellaneous

  • Job located in South San Francisco
  • Start date: As soon as possible.
  • Travel up to 25%

Recruitment process

Phone interview with manager
Day Interview with manager, cofounders, HR and the team
References Check
Timing: 2-3 weeks

Apply now

The role

We are looking for an experienced HR Manager, US to manage a variety of HR projects for the US site. The HR Manager, US will plan, lead, direct, develop, and coordinate the policies, activities, and staff of the US HR department, ensuring legal compliance and implementation of the organization’s mission and talent strategy. The candidate will be in contact with external recruiters, lawyers, management team in the US, and the French HR team to coordinate the deployment of the HR strategy. The position reports to the Vice-President, Corporate Operations, based in France.

Responsibilities

Hiring and onboarding

  • Contribute to the definition of a global strategy to lead adhesion to and promotion of the company’s core values: Excellence, Transparency and Goodwill, on the South San Francisco site.
  • Contribute to the definition of a global strategy to identify and hire top performers and lead its execution on the South San Francisco site.
  • Contribute to the definition of a global strategy to integrate, incentivize and retain talents, in particular key employees, and lead its execution on the South San Francisco site.
  • Liaise with the broader US management team to understand the company’s goals and strategy related to staffing.
  • Collect and qualify needs for US-based positions with respect to budget and business requirements.
  • Manage end-to-end hiring process for US-based positions, including job posting, headhunter management, support of hiring managers during the interview process, contract drafting and onboarding.
  • Suggest process improvements and implement them in the most effective way.

Training, performance and retention

  • Liaise with the broader US management team and US employees to understand training needs.
  • Define and implement a talent development and retention strategy for US-based employees, in connection with the company’s global strategy.
  • Organize, implement and monitor mandatory trainings (security, quality, harassment, etc.).
  • Define and create internal training material.
  • Lead the performance review process for US-based employees.
  • Administration
  • Draft all relevant contractual documents, including offer letters, employment contracts and termination letters.
  • Oversee administration of compensation, benefits, time-off policies, visa requests, etc.
  • Lead exit interviews, disciplinary procedures, disputes, and investigations.
  • Ensure continued compliance with federal, state, and local employment laws and regulations, and recommended best practices.
  • Ensure compliance of HR processes for US-based employees with relevant data protection regulations (e.g. CCPA if/when relevant) and any quality requirements with which the company wishes to engage.
  • Define and implement budget and KPIs.
  • Prepare reports and presentations for management and/or company-wide meetings.

HR marketing and communication

  • Update and adapt HR internal and external communication tools (employee handbook, social networks, career website, etc.) to the US context.
  • Develop a common company culture in collaboration with the French HE team.
  • Organize events to promote company culture and wellness (e.g. seminars, dinners, etc.).
  • Benchmark cultural and managerial practices against best-in-class companies for continuous improvement.
  • Cross-functional projects
  • Administer occupational health and safety.
  • Conduct research and analysis of organizational trends including review of reports and metrics.

Preferred experience

Essential

  • Bachelor’s degree in Human Resources, Business Administration, or related field required; Master’s degree preferred.
  • At least five years of experience in human resource management required.
  • Thorough knowledge of employment-related laws and regulations, in particular in California.
  • Ability and willingness to get things done.
  • Ability and willingness to manage projects at operational level.
  • Strong analytical and problem-solving skills.
  • Excellent verbal and written communication skills.
  • Excellent organizational skills and attention to detail.
  • Excellent reporting skills.
  • Excellent time management skills with a proven ability to prioritize and meet deadlines; ability to efficiently mobilize external resources and coordinate projects.
  • Ability to work in a global organization.
  • Proficient with Microsoft Office Suite or related software.

Desirable

  • Experience in the biotech industry.
  • Start-up mindset.
  • Experience in a scale up environment.

Additional Information

  • Job located in South San Francisco
  • Start date: ASAP

Recruitment process

  • Phone interview with the hiring manager
  • Day interview with manager, cofounders, HR and the team
  • References check
  • Timing: 2-3 weeks
Apply now

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionately impatient people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”. We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our SYNTAX DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have a far-reaching impact across biological sciences.

The Role

We are seeking a commercial operations Manager to help the Sales and Support organization with our CRM, reporting and development of new analytical tools. This person will be responsible for hiring, training and supervising customer service representatives. This person will be an integral part of the commercial team helping to create new tools to increase the visibility and alignment across several functions. Someone who is collaborative, transparent and seeks to create new and improve on existing processes will be a great addition to the DNA Script team.

Responsibilities:

  • Work with Commercial leaders on critical strategic, organizational, and operational projects designed to increase revenue, sales productivity, and operational efficiency
  • Provide thought leadership, perform business analysis, and support execution of high-impact strategic projects and mission-critical initiatives
  • Hire, train and manage Customer service representatives for order entry, and customer communication.
  • Review, improve and develop reports to be used by the commerciateams in support of daily operations, monthly/quarterly metrics and business initiatives
  • Facilitate implementation, development and maintenance of Netsuite CRM functionality in a cross-functional team environment, working closely with contractors and DNA Script teams
  • Develop a Forecasting tool and collaborate with Finance and Sales on monthly forecasting cycles
  • Own quarterly revenue projection process, including model updates and meeting facilitation with key Sales and Operations leadership
  • Lead and or participate on cross-functional teams to develop improved processes and communication in support of business initiatives
  • Identify and implement process improvements with the goal of streamlining Order Entry to Order Fulfillment portion of commercial business process
  • Understands and communicates strategic and tactical directions to ensure consistent and cohesive business objectives interdepartmentally
  • Create and update work instructions and process maps
  • Effectively communicate with manufacturing, logistics, sales, finance, and product marketing groups to support process implementation and improvements
  • Plan and monitor operational initiatives to improve the efficiency and effectiveness of customer care
  • Performs other duties as required

Preferred experience

Requirements:

  • A relevant Bachelors Degree, or a Masters Degree in technical or business related discipline
  • 3+ years’ experience in an operations role
  • Previous experience working in or with Sales, Finance, customer service, order management, field support, or similar groups in an analyst position
  • Previous Life Science or Clinical Industry experience a plus
  • Experience working with ERP and CRM systems. Netsuite knowledge preferred
  • Previous experience developing or running reports using BI tools
  • Experience using Microsoft suite including: Word, Excel, Outlook, Power Point, etc.
  • Strong analytical skills and ability to effectively communicate complex topics concisely
  • Very strong Microsoft Excel experience
  • Ability to collaborate and communicate across all levels of the organization and effectively balance commercial and operational needs
  • Ability to handle multiple tasks, embrace change, and innovate in a fast past environment
  • Ability to handle stressful situations and demonstrate strong problem solving skills
  • Ability to develop and present information to commercial leadership
  • Ability to effectively lead, plan and execute on plans for process improvement

Nice to have & background:

  • Management Experience a plus
  • Experience with Field Service and Case Management activities facilitating metrics development
  • Familiar with ISO13485 quality management system and supporting report development to satisfy tracking and trending of product quality.

Recruitment process

  • Phone Interview with manager
  • Day Interview at the office with manager, HR, cofounders and the team
  • References Check
  • Timing: 2-3 weeks
Apply now
Manufacturing Operations

Descriptif du poste

Responsabilités

Gérer les stocks nécessaires à la production:

  • Sorties et entrées du stock, commandes du matériel nécessaire, inventaires des matières premières et consommables, etc.
  • Assurer la réception et le suivi des stocks des matières premières, articles de conditionnement et consommables nécessaires à la production
  • Interagir avec les équipes Supply Chain pour coordonner la production

Produire les kits

  • Assurez la préparation et le conditionnement des kits dans le respect des protocoles internes, et saisir toutes les transactions dans l’ERP (NetSuite)
  • Exécuter le planning de production tel qu’établi par la Supply Chain
  • Garantir les volumes de production attendus et une qualité de production constante

Suivre la qualité de la production

  • Surveiller et assurer la maintenance des instruments de laboratoire utilisés pour la fabrication
  • Assurer la traçabilité de chaque matières premières et consommables utilisés pour les kits et la production
  • Gestion documentaire dans le respect des normes réglementaires

Assurer la préparation des expéditions vers notre filiale et nos clients

  • Approvisionner les articles de conditionnement
  • Déclencher et suivre les expéditions (température ambiante et à -20°C)
  • Mettre à jour les stocks dans l’ERP

Participer à l’amélioration continue des méthodes de production

  • Proposer des améliorations des pratiques et des méthodes de production mises en place afin d’assurer la montée en cadence due à la commercialisation
  • Être acteur de l’amélioration continue de la qualité

Profil recherché

Expérience

  • Licence en Biologie, Chimie, Biochimie ou domaine connexe
  • 1 à 3 d’expérience sur une fonction similaire
  • Expérience en laboratoire
  • Expérience de travail avec un ERP
  • Respect des règles de sécurité et des référentiels internes de qualité et réglementaire
  • Bonne organisation et autonomie
  • Travail d’équipe
  • Organisé(e) et assidu(e)
  • Maîtrise du Français
  • Anglais technique

Déroulement des entretiens

  • Entretien téléphonique avec le hiring manager
  • Entretiens dans nos locaux avec le manager, les cofondateurs, RH et le reste de l’équipe
  • Prise de références
  • Timing: 2 à 3 semaines

Le lien de l’offre est disponible ici pour postuler: https://www.welcometothejungle.com/fr/companies/dna-script/jobs/technicien-ne-de-production-et-logistique_le-kremlin-bicetre

Apply now

Opportunity and challenges

We are looking to assemble a team of best-in-class, innovative and passionate people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”. We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a Manufacturing & Procurement Technician who will be primarily responsible for the preparation of kits under good laboratory practices. This role will include inventory follow up, execute products preparation to build the kits with full traceability and interact with R&D teams to support customer demands. In addition, she/he will be responsible for procurement of all necessary items for kits production.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.

The position will be US based, in the South San Francisco, California office.

Responsibilities:

  • Prepare buffers, solutions, and other kit components following approved protocols, including the use and safe handling of hazardous chemicals, data input and record keeping
  • Use approved analysis techniques to characterize and ensure quality of synthesis reagents and products
  • Work with supply chain team and our ERP (NetSuite) to optimize packaging and shipments, eliminating back orders
  • Maintain inventory for laboratory and manufacturing operations @ SSF site
  • Maintain finished goods inventory, work in process and raw materials; recommend material orders as needed to maintain stocks for production
  • Monitor, qualify, and maintain calibration of laboratory instrumentation used for manufacturing
  • Participate in planning activities pertaining to kit production
  • Help in writing all QC procedures in coordination with Paris office QA team
  • Perform reagent manufacturing, logistics planning and other tasks as necessary in a laboratory environment
  • Assist in assembly and packaging of reagents and consumables for both domestic and international shipment
  • Procure and receive materials to support kit production and shipping
  • Execute tasks under approved SOPs, document production using batch records and contribute to improving overall quality in operations
  • Contribute to development and execution of incoming inspection of received goods and stability tests
  • Work under the supervision of Manufacturing Operations management

Experience:

  • Bachelors degree in Biology, Biochemistry, Chemistry or related field.
  • 1-3 years of relevant experience is preferred
  • Experience working in laboratory
  • Experience working under GLP (Good Laboratory Practices) and following good documentation and compliance practices
  • Experience with laboratory safety procedures and documentation
  • Detail oriented and meticulous attention to detail
  • Willingness to take/accept new responsibilities and able to work with minimal supervision.
  • Demonstrated ability to work in multidisciplinary teams

Miscellaneous

  • Job located in South San Francisco
  • Start date: Q3 2021

Recruitment process

  • Phone interview with the hiring manager
  • Day interview with manager, cofounders, HR and the team
  • References Check
  • Timing: 2-3 weeks
Apply now

The role

DNA Script is looking for a Enzyme Manufacturing Manager to strengthen the production of its proprietary enzymes. You will lead the new enzyme production team and be in charge of the fermentation and purification activities under the supervision of the Manufacturing Operations Director. You will be in charge of managing the production process of different enzymes at pilot scale in order to assure the production of those enzymes. You will have to collaborate with other teams, especially enzyme R&D teams, to secure DNA Script technology.

Responsibilities

  • Supervise USP and DSP teams
  • Maintaining detailed documentation of all work process
  • Manage operational activities in fermentation and purification areas (production and optimization implementation)
  • Take immediate corrective actions when necessary
  • Help to develop robust processes and support process transfer to external partners
  • Manage scale-up and implementation of the USP / DSP processes for multiple enzymes, and validate new processes
  • Support generation of WIs, SOPs, batch records and reports for internal tracking and QMS requirements
  • Recognize and resolve technical problems and evaluate options for complex problem solving
  • Participate in routine maintenance and lab safety by following laboratory procedures and good laboratory practice
  • Maintaining laboratory safety practice
  • Participating production team meeting and presenting technical report

Qualifications and experiences

  • Hold a Master/Engineer degree or PhD preferably in biochemistry, protein fermentation and purification, biotechnology or related fields
  • 8+ years of experience in proteins production
  • Extensive theoretical knowledge and hands-on experience with chromatography techniques
  • Industrial experience in scale-up at pilot/commercial scale
  • Demonstrated management and leadership skills of scientific team
  • Excellent oral and written communication skills in English, good level of French is a plus
  • Proactive with excellent team spirit
  • Appreciate lab work in a dynamic and evolving environment

Miscellanous

  • Job located in Kremlin-Bicêtre (Paris area, 5 minutes from Porte d’Italie)
  • Start Date: September 1st

Recruitment process

  • Phone interview with the hiring manager
  • Day interview at the office with manager, cofounders, HR and the team
  • References Check
  • Timing: 2-3 weeks
Apply now

The role

The Chemical Laboratory Engineer will be working in the nucleotide production team to conduct internal production of nucleotides, one of the key reagents in DNA Script’s technology. Under general supervision of the Manufacturing Manager and following written work instruction, your task will be to synthesize and purify nucleosides/nucleotides and derivatives thereof, as well as to prepare nucleotide reagent kits, and to perform other laboratory tasks assigned. You will perform quality analysis and purifications utilizing high-performance liquid chromatography (HPLC) as well as flash chromatography (FC) while maintaining detailed documentation of all work processes. You will also assist the Manufacturing Manager in production planning and daily operations.

Responsibilities

  • Production of nucleosides and nucleotides according to work instruction (WI) and batch manufacturing record (BMR)
  • Preparation of nucleotide reagent kits, formulation and packaging
  • Maintaining detailed documentation of all work process
  • Assisting Manufacturing Manager with production planning, daily operation and management of production technicians performing other laboratory tasks assigned by Manufacturing Manager
  • Participating production team meeting and presenting technical report
  • Maintaining laboratory safety practice

Experience and skills

Essential:

  • Holds a Bachelor degree in the field of Chemistry or Chemical Engineering
  • 2 – 7 years of experience in research or industrial laboratory settings
  • Good knowledge in general chemistry, including but not limited to laboratory skills, data interpretation from various spectroscopic techniques
  • Experience in various analytical and purification methods and instrumentation: pH meter, UV-Vis spectrophotometry, thin-layer chromatography, flash column chromatography, HPLC
  • Strong record keeping skills
  • Ability to work independently and in a team environment
  • Fluent in English (speaking, reading and writing reports)

Desirable:

  • Experience in ERP system (NetSuite), EBR (Electronic Batch Record) and QMS

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP

Recruitment process

  • Phone Interview with manager
  • Day Interview with manager, cofounders, HR and the team
  • References check
  • Timing: 2-3 weeks
Apply now

The role

We are looking for a Purchasing Manager to support our Manufacturing Operations team, for inventory and non-inventory items. The ideal candidate will be responsible for securing the supply contracts of key suppliers, negotiate purchase conditions, implement supplier agreements, manage cost reduction while continuing to ensure quality of purchased products and improve supplier performance. He will also be supporting the suppliers analysis and supplier audit process in coordination with the Quality Assurance Manager.

The position is US based, in the South San Francisco, California office.

Responsibilities

Your main missions will be the following ones:

  • Analyze data or insights to determine industry and market trends
  • Negotiate purchase conditions and contracts with vendors (price, schedule, quality, and terms) on the defined portfolio : raw materials, packaging materials, electronic components and instruments
  • Implement and manage supplier agreements
  • Execute strategies and tactics to achieve best results regarding pricing, logistics, inventory, and payment terms
  • Analyze impact to determine the best value supplier
  • Devise long-term strategies aimed to reduce raw material landed costs while satisfying a continuous and steady supply
  • Study and propose real back-up and second source strategy (product group, regional …)
  • Manage International Supplier Relationships and foster trust relationships with vendors to achieve better pricing and quality of services
  • Support and assist other departments to ensure efficient flow of purchasing transactions throughout the company
  • Scout and present alternate raw materials and new technological solutions
  • Assume responsibility of budget development
  • Report periodically summary results and defined KPIs to head of Manufacturing Operations

Preferred experience

Qualifications and experience

  • Bachelor’s degree in Business Administration and a minimum of 3 years of relevant experience in the field
  • Knowledge of Biotech environment
  • Knowledge of MRP/ERP software required (ideally NetSuite / Oracle)
  • Good judgment in price negotiation and vendor selection
  • Experience in managing capital expenditure on many projects going on
  • Decisive and excellent problem-solving skills
  • Ability to work under pressure
  • Strong analytical skills
  • Ability to plan, organize, and manage multiple projects with attention to detail
  • Ability to handle changing priorities under tight deadlines

Recruitment process

Phone interview with manager
Day interview with manager, HR, cofounders and the team
References check
Timing: around 2-3 weeks

Apply now

Opportunity and challenges

We are looking to assemble a team of best-in-class, innovative and passionate people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”. We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a Supply Chain Coordinator who will report directly to the Manufacturing Operations Director.
You will be responsible for ensuring daily follow-up and creating a world class customer service experience as you input to and execute the Customer Service Strategy. You will work in close collaboration with Manufacturing Operations, Sales and Marketing, Field Services and Support and all internal services.
The position is based in Paris.

Responsibilities :

  • Improve customer service experience, create engaged customers and facilitate organic growth
  • Take ownership of customers issues and follow problems through to resolution
  • Managing the timely and accurate processing of inbound requests from customers
  • Set a clear mission and deploy strategies focused towards that mission
  • Develop service procedures, KPI’s, policies and standards
  • Analyzing and summarizing customer feedback and requests for changes
  • Propose ways of improving customer satisfaction, optimization of processes, devices, tools, etc.
  • Keep accurate records and document customer service actions and discussions
  • Analyze statistics and compile accurate reports
  • Recruit, mentor and develop customer service agents and nurture an environment where they can excel through encouragement and empowerment
  • Keep ahead of industry’s developments and apply best practices to areas of improvement
  • Control resources and utilize assets to achieve qualitative and quantitative targets
  • Adhere to and manage the approved budget
  • Maintain an orderly workflow according to priorities

Experience :

  • Bachelor degree in Supply Chain Engineering or equivalent
  • Proven working experience as a Customer Service Manager, Retail Manager or Assistant Manager
  • Experience in Medical / Biotech, medical device or Life science tool
  • Experience in providing customer service support
  • Able to demonstrate a history of managing project in a technical or scientific context
  • Excellent knowledge of management methods and techniques
  • Working knowledge of customer service software, databases and tools (ideally NetSuite)
  • Strong sense of service: analytical and thinking skills to formulate the best responses to customers
  • Strong client-facing and communication skills
  • Ability to think strategically and to lead
  • Advanced troubleshooting and multi-tasking skills
  • Excellent presentation
  • Awareness of industry’s latest technology trends and applications
  • Fluent in English

Recruitment process

  • Phone interview with manager
  • Day interview at the office with manager, cofounders, HR and the team
  • References check
  • Timing: 2 to 3 weeks
Apply now
Product Development

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionate people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”. We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.

The position will be US based, in the South San Francisco, California office.

Responsibilities:

  • Interpret and define requirements and technical specifications for existing and new automation platforms, modules, and test-beds
  • Participatie in or lead the selection, evaluation and integration, of electronic and electro-mechanical components such as motors, sensors, controllers, and drivers
  • Design, simulate, integrate, test, characterize and troubleshoot PCBAs and related components
  • Extract and analyze data from sensors and other components to assess or characterize performance, determine root-cause of failures and make adjustments or design changes as necessary
  • Design schematics and printed circuit board layouts for new electronics designs including low-noise analog, power electronics, and high-speed digital circuits
  • Work with cross-functional engineering team (electrical, mechanical, software, etc.) to develop coordinated solutions to sophisticated problems
  • Prototype, test, and bring-up circuits for robotic devices to ensure signal integrity, performance, and functionality
  • Write electronic hardware documentation and generate electronic release packages in accordance with quality standards
  • Participate in subsystem failure mode analysis to ensure safe and efficacious system designs

Preferred experience

Experience:

  • A Bachelor’s degree, or higher, in Electrical Engineering or equivalent experience.
  • 2+ years of relevant industry experience designing, building, and supporting electronics and electrical sub-systems life science instrumentation or diagnostic devices.
  • Proficiency with common electrical test and measurement equipment such as oscilloscopes, logic analyzers and communication bus packet sniffers
  • Solid understanding of physics and electrical engineering fundamentals
  • A positive, proactive attitude and a strong passion for science, engineering and high-impact product development
  • Demonstrated success working in multidisciplinary team environments
  • Experience with one or more electrical design tools for schematic capture, layout and cable documentation

Ideal Candidate will have:

  • Experience with or understanding of basic design control under ISO standards and knowledge of how they relate to electrical components and designs
  • Experience with development of Firmware and Embedded Code.
  • Experience with Python for analysis, modeling and simulations.
  • Experience with Python or C++ for device control and data acquisition.
  • Experience with electrical control in one or more of the following areas: Motion (stepper and/or BLDC servo motors), thermal (TECs, PID, thermistors, thermocouples, RTDs, cartridge heaters, etc), and fluidic/pneumatic (cylinders, pumps, valves, solenoids, regulators, sensors)
  • Knowledge of complete electrical board design cycle.

Recruitment process

  1. Phone interview with the hiring manager
  2. Day interview at the office with the manager, cofounders, HR and the team
  3. References Check
  4. Timing: 2-3 weeks
Apply now

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionate people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”. We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.

The position will be US based, in the South San Francisco, California office.

Responsibilities:

  • Design or modify mechanical engineering layouts, schematics, and CAD models and/or detailed drawings and specifications of moderate scope
  • Perform and document engineering tests
  • Generate related Design Control documentation for product release
  • Coordinate the procurement and assembly of mechanical components and equipment and identify sources of critical parts and subsystems to resolve complex technical issues
  • Troubleshoot a variety of mechanical issues
  • Implement concepts and mechanical solutions
  • May be responsible for the design, development and implementation of custom mechanical tooling, fixturing, and associated processes to enable the handling, assembly and/or disassembly of parts, components, sub-assemblies and final assemblies throughout the product life cycle

Preferred experience

Experience:

  • A Bachelor’s degree, or higher, in Mechanical Engineering.
  • 0-2 years of relevant industry experience in mechanical engineering of life science instrumentation or diagnostic devices.
  • Experience using 3D modeling methodology and tools, ideally Solidworks.
  • Knowledge of key development tools and design standards: 3D CAD, Finite Element Analysis, Tolerances, Manufacturing Principles
  • Knowledge of Mechanical Engineering Design specializations or competencies: Tolerance Analysis, DFM, Serviceability
  • Knowledge of specific component industry standards.

Ideal Candidate will have:

  • Experience with or understanding of basic design control under ISO standards and knowledge of how they relate to mechanical components and designs
  • Experience prototyping and validating designs in a system.
  • Experience with Python for device control and data acquisition.
  • Experience in one or more of the following areas: Motion (stepper and/or BLDC servo motors), thermal (TECs, PID, thermistors, thermocouples, RTDs, cartridge heaters, etc), and fluidic/pneumatic (cylinders, pumps, valves, solenoids, regulators, sensors)
  • Knowledge of product development lifecycle

Recruitment process

  1. Phone interview with the hiring manager
  2. Day interview at the office with the manager, HR, cofounders and the team
  3. References Check
  4. Timing: 2-3 weeks
Apply now

We are looking to assemble a team of best-in-class, innovative and passionate people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”. We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a motivated and efficient Engineering Technician who will be focused on enabling and testing our DNA synthesis technology and the development of DNA Script’s commercial product. This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.

The position will be US based, in the South San Francisco, California office.

Responsibilities

  • Work closely with team members to improve quality and performance of mechatronic and automation platforms
  • Perform mechanical, electrical, and fluidic tests on prototypes. Document results clearly, using approved templates
  • Operate, maintain, and perform advanced service on prototypes. Address issues in a timely manner.
  • Troubleshoot, repair and requalify prototypes and associated test equipment .
  • Assemble components, subsystems, and systems for testing.
  • Perform operational test and fault isolation on systems and equipment.
  • Assist in determining methods or actions to remedy malfunctions.
  • Assist in the design, construction, test and check-out of test equipment.
  • Use manufacturing, test, development, and/or diagnostic equipment, including, but not limited to, test programs, oscilloscopes, signal generators and specialized test apparatus.
  • Work closely with development engineers to conduct engineering tests, collect performance data, and/or assist in research work.
  • Maintain a clean work environment including instruments and equipment and workspace

Preferred experience

  • Bachelor’s degree in engineering discipline with 1 year of experience

Ideal Candidate will have:

  • Experience with instruments including electromechanical systems, especially linear actuators and fluidics.
  • Extensive experience diagnosing and correcting problems with instruments or equipment.
  • Experience and aptitude with testing light mechanical systems.
  • Familiarity with electrical circuits and power supplies.
  • Ability to follow documented procedures as well as keep organized lab notebook
  • Experience using mechanical tools to assemble and disassemble instrument components, modules, and full systems
  • Experience working on analytical instruments combining mechanisms, electronics, automation, and fluidics.
  • Hands-on experience with breadboard/prototype builds and automation/fluidics optimization.
  • Ability to troubleshoot electronic circuits.
  • Experience in reliability or life testing. Experience developing fixtures and instrumentation for assembly and testing.

Recruitment process

  1. Phone interview with the manager
  2. Day interview at the office with the manager, cofounders, HR and the team
  3. References check
  4. Timing: around 2-3 weeks

Miscellaneous

  • Job located in South San Francisco
  • Start date: Q2 2021
Apply now

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionate people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”. We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our DNA Synthesis platform will not only have the potential to change the way the world makes and uses synthetic DNA but will also accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is looking for an experienced Product Development Engineer to join our team, in a role that is focused on improving and expanding the capabilities of the company’s core synthesis platform. The candidate will be responsible for managing and improving the platform’s design documentation and ensuring product requirements clearly trace through to specifications and verification & validation protocols.

The candidate is expected to lead requirement generation, development of acceptance criteria and verification test cases, risk analysis, generation of specifications and participate in efforts to design improvements to the system. Additionally, the candidate will work collaboratively with the R&D team in Paris, engineering partners and software development.

The candidate will join a global team bringing together scientists from various fields of expertise. We are looking for a person who is rigorous, well organized and detail-oriented. Pro-active, the candidate should be a problem-solver and should have a strong ability to think “out of the box”, as well as willingness to suggest and to prove out new ideas.

The position will be based in the South San Francisco, California office.

Responsibilities:

  • Work closely with program management, field support, software and hardware teams to understand requirements, contribute to product improvements and new design activities, and develop associated verification and validation test criteria and procedures
  • Maintain traceability for on-market products between test reports and requirements, specifications, failure modes analysis, and CAPAs, throughout design controls.
  • Write and maintain design history file documentation
  • Write test protocols, conduct feasibility, verification, and validation testing, and record results in a clear, concise, and compliant manner.
  • Lead & perform efforts involving system robustness & stability. Conduct root cause analysis investigations; identify failure modes and resolutions.
  • Conduct periodic risk management reviews, updating design, process and use FMEAs.
  • Ensure all aspects of product testing and execution are performed within pre-specified program plans (including documentation such as protocols, reports, statistical analysis, deviations, root cause investigations).
  • Ensure that the product meets performance requirements, intended use, and user needs by
    conducting engineering tests, inspections, stability tests, and usability tests to evaluate individual components, subsystems, or the overall design.
  • Establish and maintain schedules to meet critical milestones.
  • Work with 3rd party vendors and cross-functionally to advance product development and testing.
  • Conduct failure investigations/root cause analysis for issues identified by field support and summarize evaluations and results through written or oral presentations.
  • Work cross-functionally to receive, prioritize, and implement design changes to improve quality and performance of DNA Script’s products in response to customer complaints and feedback

Preferred experience

  • BS or higher in engineering, chemistry, biochemistry, or related field
  • Minimum of 5 years’ experience working in continuing engineering or new product development involving biotechnology instrumentation, operating under design controls (21 CFR 820.30)
  • Experience creating and managing product requirement documentation & trace matrix
  • Experience creating design and product specifications
  • Experience troubleshooting/developing liquid handling automation systems, mechanical and electrical systems
  • Strong documentation skills and ability to effectively communicate verbally and in writing, utilizing Word, PowerPoint and Excel

Ideal Candidate will have:

  • Ability to organize and manage design documentation, respond to changes, and prioritize effectively
  • Strong analytical mindset, detail oriented, and adept at communicating ideas, concepts, and presenting data
  • Ability to solve complex problems and troubleshoot dynamic systems
  • Versatile and adaptable to new methods, technologies and approaches
  • Past experience developing systems for NGS / PCR applications is a plus
  • Excellent communications skills
  • Proactive, solutions-focused

Recruitment process

  1. Phone interview with the hiring manager
  2. Day interview with manager, cofounders, HR and the rest of the team
  3. References check
  4. Timing: 2-3 weeks
Apply now

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

The Role   

DNA Script is actively searching for an accomplished Field Service Engineer to support our partners and customers in their use and application of DNA Script’s commercial product. 

The individual will be responsible for leading complex technical inquiries in the field including troubleshooting and repairs, coordinating customer feedback and interactions, and representing user experiences within the company to aid development of next generation products. 

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have a far-reaching impact across biological sciences.    

The position will be remote based in the San Francisco Bay area and within commuting distance of our South San Francisco, California office.

Responsibilities

  • Installs and optimizes hardware/software/network products and configurations at customer sites.
  • Diagnoses and resolves product performance problems.
  • Performs maintenance and repairs.
  • Documents all field activity performed and ensures timely escalation of difficult issues for quick resolution.
  • Ensures customer satisfaction by advising customers on preventive maintenance and configurations, which may impact product performance.
  • Proactively responds to potential equipment issues to prevent unplanned interruption of customers’ business.
  • Delivers fully integrated solutions, which may include peripherals, communications, operating systems and applications software.
  • Train other field engineers and customers in the company’s system products. 
  • Serve as the primary point of contact for support within the western United States region ensuring all inquiries and complaints are documented, and customers are kept informed of issue resolution. May occasionally be required to provide support in other geographic areas.
  • Provide user-oriented and service-related  input to ongoing and new development projects.
  • Provides support of instrument operations and participates in product training within our South San Francisco  laboratory.
  • Represents DNA Script to customers and ensures customer satisfaction and high-quality service and support experiences. 
  • Ensures customer inquiries, complaints and outcome of service activities are documented in the company’s database.

Experience

  • Bachelors degree within the science field — e.g. biomedical engineering,  analytical biochemistry, biotechnology or similar is highly preferred
  • 4+ years of experience in a similar position and/or experience as an end-user of analytical instrumentation
  • Associates degree within the engineering field (electronics, mechanical) will be considered with 6+ years experience in a similar position working with qPCR instruments and liquid handling robotic systems.

Ideal Candidate will have

  • Experience or expertise with Laboratory Automation solutions (eg. pipetting robots, electronics and linear actuators) and systems involving reagents and consumables
  • Experience with troubleshooting and problem solving. Customer service and solutions-oriented, with capability to precisely document issues, root cause analyses, troubleshooting experimentation and resolutions/repairs.
  • Ability to effectively communicate with customers to ensure understanding of services and troubleshooting performed, as well as ensuring overall customer satisfaction with company products.
  • DNA Synthesis Experience, or Utilization of Synthetic Oligos in a biochemical application.
  • Excellent written and verbal communication skills.
  • Works well in a collaborative team environment but is also able to work independently.
  • Ability to collect technical data and produce high quality and professional presentation materials to communicate data and conclusions internally to stakeholders such as marketing and development teams to transfer knowledge about key field issues.
  • Ability to travel extensively including overnight travel as dictated by business needs

Miscellaneous

  • Remote job based on the West Coast of the USA. Requires up to 75% travel to corporate offices and client sites throughout Western region of the US and other parts of North America.
  • Start date: Q2 2021
Apply now

The Role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a Senior Front-end Software Engineer to implement the web-based Lab Information Management System.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences. 

Responsibilities:

  • Design and develop e-commerce application supporting our business and product needs.
  • Work with product management and marketing to capture and define software requirements and influence overall product implementation direction.
  • Work closely with UX design personnel, clients and potential customers to understand their needs, objectives, and use cases, and develop applications meeting these specifications.
  • Strong technical leadership skills  with the ability to solve complex problems.
  • Constant quality improvement of code and infrastructure.

Requirements:

  • A Bachelor’s Degree, or a Master’s Degree in software engineering or related field.
  • 5+ years of software development in an e-commerce environment with various web-based applications, web store, inventory, order management, analytical reports, etc.
  • Prior experience developing and launching web-based SaaS on AWS and/or stand-alone software package.
  • Experience developing web applications using TypeScript, ReactJS, Apollo, and GraphQL (or JSON) API.
  • Experience integrating with third party solutions via web services API.
  • Experience with Atlassian applications including BitBucket, Jira, Confluence, and other 3rd party development tools and utilities.
  • Self-motivated, self-starting, an attention to detail and a great team player.
  • The highest level of personal honesty, integrity and commitment; unquestionably walks the talk so others want to follow.
  • Strong communication skills.

Ideal Candidate will have:

  • Familiarity with enterprise NGS cloud-based systems, ideally Illumina / Design Studio
  • Background in biological sciences, DNA applications, either from education or work experience.

Miscellaneous

  • Job located in Paris, France
  • Start date: ASAP 
Apply now
Regulatory and Quality

The role

We are looking for a Validation Engineer to oversee validation activities at DNA Script. The Validation Engineer will define, plan, develop and coordinate the validation strategy in compliance with the requirements of ISO13485 and 21 CFR Part820. The ideal candidate must be autonomous, with good leadership skills, Quality Mindset, with the ability to handle multiple tasks in parallel, and communicate effectively.
The position reports to the Quality Assurance Engineer, Quality and Regulatory Department, based in France.

Responsibilities

  • Definition and implementation of the validation strategy (analytical, manufacturing and utility processes)
  1. Write and implement the Validation Master Plan
  2. Carry out the critical evaluation of the methods,
  3. Identify possibilities for improving methods to optimize their stability and robustness,
  4. Help to define the acceptance criteria,
  5. Drafting of validation protocols according to the regulatory texts in force,
  6. Carrying out and monitoring initial and periodic validation tests,
  7. Writing of validation protocols and reports,
  8. Validation of these validation documents by demonstrating their relevance according to the performance standards to be achieved.
  • Ensure the implementation of the validation and / or qualification strategy by planning activities,
  • Assist in the industrial scale-up of the processes defined at the laboratory scale: validate the processes at a production scale in compliance with the defined performance standards,
  • Support the industrialization of new processes on the production site by providing the necessary documentation,
  • Help ensure the operational maintenance and validation of utilities and equipment through the planning and management of preventive maintenance and qualification,
  • Provide expertise to quality control and production in the event of analytical anomalies, investigations, or complaints.

Preferred experience

Essential

  • Bachelors’ or Masters’ Degree in Engineering, Pharmacy or equivalent.
  • At least 3-5 years of experience in validation & qualification of chemistry/biology industrial processes or at least 5 years of experience working in validated environment with direct participation in validation processes
  • Mastery of the fundamentals of validation (PV, QI, QO, QP and RV)
  • Knowledge of regulatory requirements concerning the qualification and validation of analytical methods (ICHQ2(R1))
  • Experience of working in a regulatory environment (ISO 9001/13485, 21CFR Part820 or BPF/GMP)
  • Autonomy, rigor, and proactivity
  • Good written and verbal communication skills in French and in English

Desirable

  • Experience in the biotech/pharma industry.
  • Awareness of risk management
  • Start-up mindset.

Recruitment process

  1. Phone interview with the hiring manager
  2. Day interview at the office with the manager, cofounders, HR and the team
  3. References Check
  4. Timing: 2-3 weeks
Apply now

We are looking to assemble a team of best-in-class, innovative and passionate people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”. We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a Quality and Regulatory Affair Director who will report directly to the CEO and be responsible of the creation and the management of all activities related to quality and regulatory. You will define procedures, advise operational departments, and guarantee the regulatory and quality compliance of products at each stage of their development, from concept to delivery.
In this context, you work closely with the various departments of the company (R&D, Product Development, Manufacturing, Marketing, Sales, Management) and the service providers.

Responsibilities

Strategy and build-up of activity

  • Build-up the Regulatory and Quality team and activities;
  • Create and maintain quality procedures, documentation and processes for the Company to operate at gold standard from industry stand-point;
  • Lead and be responsible for product certification in different regulatory frame-work and regions, in-line with Company strategy and objectives;
  • Lead the team in place (one engineer) to complete projects according to established timelines and needs, and develop the team in France and in the US;
  • Have a comprehensive knowledge of the product and its life cycle to analyze product characteristics and to review processes, objectives and constraints within each department;
  • Identify and analyze the regulatory framework and the modalities of introduction to the European and US markets for the product. Study the ISO 9001 and ISO 13485 certifications applicable in the company, as well as the internal quality objectives required by the Management team;
  • Define, propose and put in place the Regulatory and Quality strategy to the Management team for current and new product projects, by developing several iterations taking into account the risks and trends.

Quality

  • Define and implement the QMS system and software;
  • Create quality control tools and develop procedures;
  • Provide guidance and train each department to the quality rules and procedures;
  • Analyze performance indicators and manage incidents;
  • Manage audits and relations with certifying organisms;
  • Be responsible for identifying impacts of international regulations, standards and guidance to our Quality Management System.

Regulatory Affairs

  • Propose and lead a strategy regarding regulatory frame work, Company and product certification;
  • Provide guidance and training to explain the objectives of the regulatory provisions and define the procedures within the departments;
  • Control the respect of protocols;
  • Collect from the departments the information and technical documentation necessary for the preparation of registration, authorization or declaration files, as well as for CE marking. Lead preparatory meetings;
  • Lead and be responsible for all the certification process, relation with certification bodies and fillings;
  • Ensure that authorizations are obtained within the regulatory deadlines and those required by the sales objectives;
  • Control compliance (finished product, documentation, communication). Authorize the launching of batches;
  • Carry out studies and manage audits with service providers.

Qualifications and experience

Essential

  • Masters’ Degree in Medical/Biotech Engineering, Pharmacy or equivalent,
  • At least 8 years of experience in Regulatory Affairs and Quality Assurance environment, preferably with background in Biological Sciences,
  • Experience in the build-up of a Regulatory and Quality department,
  • Demonstrated management or supervisory experience with strong interpersonal and influencing skills,
  • Experience in ISO certifications (ISO 13485, ISO 9001, etc.) and CE marking,
  • Experience in medical device or Life science tool,
  • Excellent written and oral communication skills with a strong emphasis on organizational capabilities and external communications,
  • Demonstrated flexibility and adaptability in carrying out various assignments in a concrete way,
  • Operational and concrete problem-solving mindset,
  • Excellent written and verbal communication skills,
  • Strong organization and analysis/problem skills,
  • Strong attention to detail/quality focus,
  • Familiarity with Quality concepts and practices,
  • An in-depth knowledge of European and International regulations,
  • Fluent in English.

Desirable

  • Start-up mind-set is strongly preferred,
  • Understanding of the product introduction,
  • Experience in GMP.

Recruitment process

  • Phone interview with manager
  • Day interview with manager, cofounders, HR and the team
  • References check
  • Timing: around 2-3 weeks

You can also apply directly here.

Apply now
Research & Development

Mission

Dans le cadre de son développement et de la commercialisation de sa première imprimante de synthèse enzymatique d’ADN, DNA Script recherche un(e) technicien(ne) pour la production et le contrôle qualité des supports solides de synthèse d’ADN.
Intégré à l’équipe de Chimie de Surface, le candidat sera amené à interagir avec de nombreuses équipes de R&D. Il/elle sera un support pour les activités des équipes de R&D en fournissant des nouveaux lots de supports solides selon les protocoles développés dans l‘équipe. Il/elle participera également au contrôle qualité et à la validation des lots de supports solides et des kits de synthèse destinés aux clients de DNA Script.

Nous recherchons une personne dynamique, bien organisée, rigoureuse, ayant le souci du détail, et qui est capable de travailler dans un milieu multidisciplinaire et international.

Responsabilités

  • Préparer les supports solides de synthèse d’ADN pour les équipes de R&D et les futurs clients
  • Participer aux étapes de production des kits de synthèse (pipetage, aliquotage, manipulation d’automates, étiquetage…)
  • Contribuer au développement et à la validation des protocoles de préparation des supports solides
  • Préparer les différents tampons/réactifs nécessaires à la préparation des lots de supports solides et assurer leur contrôle qualité
  • Réaliser les études de stabilité des supports solides
  • Participer à la gestion des stocks de réactifs et de supports solides
  • Appliquer et contribuer au respect des bonnes pratiques de laboratoire et des règles d’hygiène et sécurité

Profil recherché

Qualifications et expérience

Essentielles

  • Bac+2/ Bac +3 licence professionnelle en Chimie
  • 3 à 5 ans d’expérience en R&D ou Production dans une société de biotechnologie
  • Bonne maîtrise du pack Office
  • Grande rigueur et qualité d’organisation
  • Dynamisme, réactivité
  • Aptitude à travailler au sein d’une équipe multidisciplinaire
  • Excellentes compétences en communication et relations interpersonnelles

Souhaitables

  • Première expérience dans une société de biotechnologie et/ou dans un environnement de production
  • Expérience en scale-up de procédés de synthèse
  • Expérience avec la manipulation de biomolécules (protéines/ADN)
  • Expérience avec l’utilisation de spectrophotomètre UV-visible
  • Bon niveau d’Anglais (équipe internationale)

Informations diverses

Poste basé au Kremlin Bicêtre (94) – Ile de France – sortie métro ligne 7
Date d’embauche : ASAP
Contrat : CDI en fonction du profil
Rémunération : à définir selon expérience

Rejoindre DNA Script, c’est aussi:

  • Des tickets restaurants Swile
  • Des avantages CSE
  • Une prise en charge de ton navigo à 50%
  • Une mutuelle Alan 100% digitalisée
  • Une plateforme de formation en illimité !
  • Des activités tout au long de l’année (petits-déjeuners, afterwork, dîner de Noël, anniversaires, séminaire et plein d’autres surprises !)

Déroulement des entretiens

  1. Interview téléphonique avec le futur manager
  2. Day interview dans nos locaux avec le manager, les cofondateurs, RH et le reste de l’équipe
  3. Prise de références
  4. Timing: 2 à 3 semaines

Vous pouvez candidatez directement ici.

Apply now

Opportunity and challenges

We are looking for an experienced R&D Program Manager for a variety of collaborative technology development projects.

The Program Manager will assist the CTO in managing existing collaborative projects to achieve goals, which includes implementing processes, planning, budget tracking, and reporting. The Program Manager will also be in charge of exploring new opportunities (grants or industrial partnerships), setting up collaborations and assist in negotiation.

The PM will implement more project management and processes in R&D to increase productivity and ensure milestones are hit on time. He/she will align with marketing and product development teams to make sure the technology developed is efficiently transformed in to a product.

The ideal candidate must be a skilled R&D leader, with the ability to work independently, handle multiple tasks in parallel, and communicate effectively with all levels of the organization and external partners.

Responsibilities:

  • Provide management and leadership skills to drive execution on project goals for a portfolio of projects
  • Manage contracts with financing agencies and industrial partners
  • Continuously analyze and manage risks to enable successful project completion
  • Define and optimize project management and development processes, methodologies, and tools to improve organizational efficiency and effectiveness
  • Manage cross-functional resources, project timelines and project budgets required to successfully drive projects and initiatives

Preferred experience

Experience:

  • Strong technical background in molecular biology
  • At least 5 years of experience in managing technical projects (including planning, risk management, budget, etc)
  • Strong interpersonal and facilitation skills with a proven ability to effectively build relationships and achieve consensus across a wide range of functions and constituents despite natural tensions between those functions (e.g. Marketing vs. RnD).
  • Demonstrated ability to lead and achieve results by influence alone
  • Strong quantitative and qualitative skills; detail-oriented with ability to see the big picture and to work effectively at both high and detailed levels.
  • Ability to travel up to 25% domestic and internationally.

Ideal Candidate will have:

  • Start-up mind-set is preferred, demonstrated by participation in one
  • Experience in applying / managing grants
  • Experience in building / managing industrial partnerships
  • Understanding of the new product introduction and product lifecycle management processes

Recruitment process

  1. Phone interview with the hiring manager
  2. Day interview at the offices with the manager, cofounders, HR and the team
  3. References check
  4. Timing: 2-3 weeks
Apply now

Opportunity and challenges

We are looking for an experienced Director of Data Science from our R&D team in Kremlin-Bicêtre, south of Paris, FRANCE. We are creating a new team inside R&D to regroup different team members with software, data science and bioinformatics expertise. The Director Data Science will manage this team (4 team members today) and report to the CTO.

This is a unique opportunity to develop a team, build a variety of software tools (image analysis, machine learning, LIMS, sequencing pipeline, molecular biology in silico design) in a dynamic environment. Some of those tools are built to enhance R&D productivity, some others to be part of our products.

Responsibilities:

  • Managing a team of bioinformaticians and data scientists
  • Project management and reporting to senior management
  • Improving LIMS and automation SW for R&D: automated image analysis, Instrument control software support, etc
  • Building Machine Learning algorithm to predict purity of DNA synthesis from sequence
  • Building Next Generation Sequencing pipelines and dedicated sequencing analysis tools.
  • Building DNA design tools for various applications of synthetic DNA (gene assembly, multiplex PCR, amplicon seq, qPCR, etc)

Preferred experience

Experience:

  • Technical leader for 5 years in data science applied to biology / bioinformatics
  • Experience in managing developers and scientists
  • Good understanding of molecular biology (NGS, PCR, qPCR, gene assembly)
  • Knowledge of Agile project management
  • Strong technical expertise in software development, data science and bioinformatics
  • Strong quantitative and qualitative skills; detail-oriented with ability to see the big picture and to work effectively at both high and detailed levels.

Ideal Candidate will have:

  • Start-up mindset – experience in a start-up environment before
  • PhD in bioinformatics + 10 years of experience

Recruitment process

  1. Phone interview with the hiring manager
  2. Day interview at the office with the manager, cofounders, HR and the team
  3. References check
  4. Timing: 2-3 weeks
Apply now

Senior Surface chemistry Scientist – Innovative solid supports for enzymatic DNA synthesis – Paris, France

The role

DNA Script is looking for a talented individual to reinforce the Surface Chemistry team at Kremlin-Bicêtre in Paris. He or she will report to the Manager of the Surface Chemistry team and be responsible for developing and producing innovative solid supports for Enzymatic DNA Synthesis. He or she will also use analytical methods (e.g. microscopy, fluorescence) to characterize solid supports at different stages of the synthesis process by optical/confocal microscopy or other appropriate techniques. To perform these tasks, the candidate will need to be organized, proactive, detail-orientated, enjoy problem-solving, and be able to work in a multi-disciplinary environment.

Responsibilities

He/she will be responsible for:

  • Developing, testing and optimizing new solid support and chemical coupling methods adapted to a variety of enzymatic synthesis methods
  • Characterizing solid supports with different techniques (e.g. confocal/optical microscopy, fluorescence),
  • Investigating microfluidic techniques and testing microfluidic systems to produce solid supports of different sizes and compositions
  • Investigating ways to immobilize DNA onto microfluidic-synthesized solid supports and determine DNA loading,
  • Determining the behaviour of solid supports during Enzymatic DNA Synthesis and their interactions with other key reagents (enzymes, nucleotides) to increase overall oligonucleotide purity, cycle time…
  • Optimizing solid supports based on feedback from synthesis tests or customers.

Preferred experience

Qualifications and experience

He/she will:

  • Have a Ph.D degree in a relevant subject (e.g. surface chemistry, physical chemistry, colloid and polymer chemistry),
  • Possess prior experience of producing polymeric beads by microfluidics,
  • Hands-on experience with optical characterization of biomolecules (UV-Vis, fluorescence, FRET, …)
  • Hands-on experience with fluorescence characterization / confocal microscopy,
  • Ability to design, execute, interpret, and troubleshoot experiments,
  • Highly motivated, passionate about developing tools and methods
  • Excellent knowledge of Excel and other Microsoft tools,
  • Excellent organisational, analytical, and systematic troubleshooting skills,
  • Excellent communication and interpersonal skills,
  • Ability to work independently and as part of a large multi-disciplinary team,
  • Dynamic with positive attitude willing to engage at a very high level,
  • Excellent English language level
  • Intermediate French language level.

Desirable:

  • Some experience in R&D (molecular biology, diagnostics, or a related field),

Recruitment process

  1. Phone interview with the hiring manager
  2. Day interview at the office with manager, cofounders, HR and the team
  3. References check
  4. Timing: 2-3 weeks

Apply now

The role

DNA Script is looking for a highly motivated, well organized team-player to join the Enzyme Engineering team as a Research Assistant. Your role will be to help us evolve proprietary enzyme variants within an exciting, high-profile oligonucleotide synthesis project.

Responsibilities

  • Perform cloning and PCR experiments to construct mutagenesis libraries
  • Express and purify enzyme variants in various scales from 96well plate to 1 L
  • Screening of mutagenesis libraries applying multiple assays
  • Isolate plasmid DNA and determine mutant sequences
  • Participate to the characterization of optimized variants
  • Keep very good record of experimental data
  • Engagement in good laboratory practices
  • Support the team when needed

Preferred experience

Qualifications and experience

Essential

  • Bachelors’ or Masters’ Degree in Biology, Biochemistry or Chemistry
  • ‘Hand on’ working experience in molecular biology or biochemistry lab
  • Familiarity with protein handling and purification
  • Familiarity with DNA handling and purification
  • Familiarity with protein structure and sequence analysis
  • Strong record keeping skills
  • Strong interpersonal skills
  • Good command of the English language

Desirable

  • Experience in screening or enzymology

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP

Recruitment process

  1. Phone interview with the hiring manager
  2. Day interview with manager, cofounders, HR and the team
  3. References Check
  4. Timing: 2-3 weeks
Apply now

Descriptif du poste

Mission
Dans le cadre de son développement et de la future commercialisation de sa première imprimante de synthèse enzymatique d’ADN, DNA Script recherche un technicien pour la production et le contrôle qualité des supports solides de synthèse d’ADN.
Intégré à l’équipe de Chimie de Surface, le candidat sera amené à interagir avec de nombreuses équipes de R&D. Il/elle sera un support pour les activités des équipes de R&D en fournissant des nouveaux lots de supports solides selon les protocoles développés dans l‘équipe. Il/elle participera également au contrôle qualité et à la validation des lots de supports solides et des kits de synthèse destinés aux clients de DNA Script.
Nous recherchons une personne dynamique, bien organisée, rigoureuse, ayant le souci du détail, et qui est capable de travailler dans un milieu multidisciplinaire et international.

Responsabilités
• Préparer les supports solides de synthèse d’ADN pour les équipes de R&D et les futurs clients
• Participer aux étapes de production des kits de synthèse (pipetage, aliquotage, manipulation d’automates, étiquetage…)
• Contribuer au développement et à la validation des protocoles de préparation des supports solides
• Préparer les différents tampons/réactifs nécessaires à la préparation des lots de supports solides et assurer leur contrôle qualité
• Réaliser les études de stabilité des supports solides
• Participer à la gestion des stocks de réactifs et de supports solides
• Appliquer et contribuer au respect des bonnes pratiques de laboratoire et des règles d’hygiène et sécurité

Profil recherché

Qualifications et expérience

Essentielles

  • Bac+2/ Bac +3 licence professionnelle en Chimie
  • 3 à 5 ans d’expérience en R&D ou Production dans une société de biotechnologie
  • Bonne maîtrise du pack Office
  • Grande rigueur et qualité d’organisation
  • Dynamisme, réactivité
  • Aptitude à travailler au sein d’une équipe multidisciplinaire
  • Excellentes compétences en communication et relations interpersonnelles

Souhaitables

  • Première expérience dans une société de biotechnologie et/ou dans un environnement de production
  • Expérience en scale-up de procédés de synthèse
  • Expérience avec la manipulation de biomolécules (protéines/ADN)
  • Expérience avec l’utilisation de spectrophotomètre UV-visible
  • Bon niveau d’Anglais (équipe internationale)

Informations diverses

  • Poste basé au Kremlin Bicêtre (94) – Ile de France – sortie métro ligne 7
  • Date d’embauche : ASAP
  • Contrat : CDI en fonction du profil
  • Rémunération : à définir selon expérience
Apply now

The role

The Research Scientist – Nucleoside, Nucleotide and oligonucleotide Chemistry will be a part of Chemistry R&D team focusing on the continued research and development of DNA Script’s Enzymatic DNA Synthesis (EDS) technology to enhance synthesis protocols, enable customer applications, and improve product performance. You will report to the Director of Chemistry.

Responsibilities

  • Collaborate with all the functions within the company to improve Enzymatic DNA Synthesis performance and advance our technology
  • Design and execute synthesis of modified nucleotides with additional functionalities to broaden DNA Script’s EDS technology applications
  • Develop in-house nucleoside phosphoramidite chemistry and automated oligonucleotide synthesis capacity
  • Accurately document experiments and results in laboratory notebooks in a timely fashion
  • Prepare and present experimental plans, results, and reports in R&D meetings
  • Contribute to the development of the DNA Script patent portfolio and the scientific literature
  • Maintain good laboratory and safety practices

Experience and skills

Essential:

  • Holds a PhD degree in Organic Chemistry, Medicinal Chemistry or similar field with extensive training and practical laboratory experience in multi-step organic synthesis
  • Experience in nucleoside, nucleotide synthesis and purification
  • Preferred experience with nucleoside phosphoramidite chemistry and automated oligonucleotide synthesizer
  • Hands-on experience in modern isolation, purification, and analytical techniques: Flash chromatography, Analytical and preparative HPLC, LC/MS, 1H/31P NMR, UV-Vis
  • Strong publication record demonstrating ability to conduct research projects independently and collaboratively
  • Excellent written, organizational, and documentation skills
  • Excellent communication and interpersonal skills, efficient interaction with internal and cross functional team members
  • Fluent English speaker

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area), please submit your resume and cover letter in English with your application
  • Start date: ASAP

Recruitment process

  • Phone interview with manager
  • Day Interview at the office with manager, cofounders, HR and the team
  • References Check
  • Timing: 2 to 3 weeks
Apply now

La Mission

Aujourd’hui en fort développement et pour supporter la demande croissante en production d’enzymes, DNA Script recrute pour le pôle DSP un(e) assistant(e) de Recherche en Biochimie. Rattaché(e) à l’équipe purification, sous la responsabilité du responsable de l’équipe DSP, vous aurez la charge de la purification hebdomadaire de lots de protéines ainsi qu’à leur validation avant leur transfert aux équipes de développement. Vous participerez également à l’optimisation des procédés de purification.

Responsabilités

  • Être garant(e) des stocks de réactifs au sein de l’équipe DSP.
  • Effectuer les différentes étapes de DSP nécessaires à l’obtention de lots de protéines (lyse cellulaire, clarification, HPLC, concentration, échantillonnage).
  • Participer activement à la démarche d’amélioration continue des procédés avec pour objectif une industrialisation future.
  • Valider la qualité des différents lots produits par l’équipe par divers tests de contrôle qualité internes.
  • Effectuer la maintenance des appareillages (Homogenizer, HPLC, TFF…).
  • Analyser les résultats au cours du procédé de purification.
  • Plusieurs techniques pratiquées : chromatographie, SDS-PAGE, qPCR, …
  • Être garant(e) de la qualité des résultats dans le respect des protocoles du laboratoire et connaître les BPL.

Profil recherché

Qualifications et expériences

  • Bac +2/3 en Biochimie des protéines
  • 1 an d’expérience minimum en laboratoire
  • Expérience sur systèmes AKTA et logiciel UNICORN très apprécié
  • Bon niveau en Anglais (lu et parlé)
  • Personne rigoureuse, ordonnée et organisée
  • Bonne connaissance en biochimie
  • Esprit d’équipe et d’initiative
  • Connaissance et mise en pratique des BPL
  • Maitriser Word, Excel et Internet

Informations diverses

  • Poste basé au Kremlin Bicêtre (94) – Ile de France – sortie métro ligne 7
  • Date d’embauche : Dès que possible
  • Contrat : CDI à temps plein
  • Rémunération : à définir selon expérience
Déroulement des entretiens
  • Entretien téléphonique avec le manager
  • Entretiens sur une demi-journée avec le manager, les cofondateurs, les RH et le reste de l’équipe
  • Prise de références
  • Timing: 2 à 3 semaines
Apply now

The Mission

DNA Script is looking for an Enzyme QC Scientist to strengthen the development and the production of its proprietary enzymes. You will join the enzyme production team composed of 8 scientists and be in charge of the QC activity under the supervision of the enzyme DSP team leader. You will be responsible for developing, optimizing, validating, and executing appropriate QC tests for enzyme release to support R&D, process development and research grade manufacturing. You will have to collaborate with other teams to ensure the successful technology transfer into manufacturing environment.

Responsibilities

  • Develop and optimize analytical and biochemical assays for enzyme characterization, including HPLC, SDS-PAGE and Western Blot, UV/Vis and Fluorescence Spectroscopy (cuvette and multi-well plate), qPCR
  • Help validation department to realize critical evaluation of test methods in order to define acceptance criteria and to establish test method validation protocol
  • Conduct experiments to validate QC methods following the validation protocol established by the validation department
  • Document and compare testing results against control/specification limits
  • Oversee and/or lead laboratory investigations to evaluate out-of-specification and atypical results within QC test methods, including troubleshooting of invalids and monitoring method performance.
  • Conduct experiments, interpret results, draw conclusions, and recommend options for future experiments to achieve project goals
  • Support generation of WIs, SOPs, and reports for internal tracking, development processes and technology transfer.
  • Present experimental results and data analysis at group meetings as directed
  • Participate in routine maintenance and lab safety by following laboratory procedures and good laboratory practices

Qualifications and experiences

  • Hold a Master/Engineer in the field of chemistry, biochemistry, genetics, cell biology or related field
  • 4+ years of work experience in a Quality Control Laboratory
  • QC analytical method development experience, including assay optimization, assay qualification and validation, assay transfer to production and documentation
  • Strong knowledge of protein biochemistry
  • Attention to detail
  • Ability to learn new methods and systems
  • Appreciate lab work in a dynamic and evolving environment
  • Excellent oral and written communication skills in English, good level of French is a plus

Miscellanous

  • Job located in Kremlin-Bicêtre (Paris area, 5 minutes from Porte d’Italie)
  • Start Date: as soon as possible
  • 1 year contract (CDD) – possibility to extend in permanent contract
Recruitment process
  • Phone interview with manager
  • Day Interview at the office with manager, cofounders, HR and the team
  • References Check
  • Timing: 2-3 weeks
Apply now

La Mission

DNA Script réalise la synthèse enzymatique de l’ADN de façon cyclique en ajoutant un nucléotide à chaque cycle. Ce procédé itératif nécessite de répéter les mêmes étapes ; l’élongation enzymatique, des lavages, puis la déprotection de la base ajoutée. Ce protocole doit donc être impérativement automatisé de manière robuste, fiable et précise pour obtenir une synthèse de haute qualité pour des fragments d’ADN de plusieurs centaines de nucléotides. DNA Script a donc développé une plateforme de synthèse utilisant des automates, chargée de fournir des fragments d’ADN à l’ensemble des collaborateurs de DNA Script.

Cette plateforme joue un rôle central pour DNA Script en évaluant d’une part les nouveaux réactifs (efficacité, stabilité…) pour les équipes de recherche et d’autre part en fournissant des oligonucléotides de qualité à l’équipe qui développe les applications ainsi qu’à nos collaborations externes.
DNA Script recherche une personne talentueuse pour rejoindre l’équipe de la plateforme de synthèse.
Le candidat sera amené à interagir avec de nombreuses équipes différentes. Il/elle sera un support pour les activités des équipes de synthèse, effectuera les opérations quotidiennes sur la plateforme et réalisera les tests nécessaires à assurer la reproductibilité au jour le jour. Ce travail sera effectué en partie sur des systèmes robotiques de type « liquid handler ».

Nous recherchons une personne bien organisée, ayant le souci du détail, qui aime résoudre des problèmes et qui est capable de travailler dans un milieu multidisciplinaire. Le candidat devra avoir un esprit pratique et agile lui permettant de maîtriser les subtilités des systèmes robotiques. Il lui faudra comprendre à la fois la biologie moléculaire sous-jacente aux demandes des équipes et les impératifs de la plateforme afin de trouver le meilleur compromis.

Responsabilités

  • Préparer et réaliser les runs de synthèse sur différents instruments, en sachant s’adapter aux spécificités de chaque demande
  • Réaliser les étapes de PSP (Post Synthesis Process) pour l’ensemble des runs de synthèse, afin de livrer des échantillons conformes aux attentes des utilisateurs, pour leurs applications. Cette étape du process est amenée à évoluer régulièrement avec la diversité du type d’oligonucléotides que nous serons amenés à développer.
  • Préparer les différents tampons/réactifs nécessaires à l’activité des différentes équipes faisant des synthèses et participer à leur QC
  • Réaliser les opérations quotidiennes de manière efficace et reproductible, assurer une disponibilité élevée des équipements en réalisant des opérations de maintenance préventive (test de dispense, reproductibilité…)
  • Eventuellement réaliser des runs de synthèse sur le SYNTAX
  • Contribuer au développement et à la validation des protocoles de synthèse automatisés ; en fonction du degré d’autonomie du candidat
  • Participer aux étapes de manufacturing nécessaires à la préparation de kit pour usage interne (études de stabilité,
  • Appliquer et contribuer au respect des bonnes pratiques de laboratoire
  • Contribuer activement à la réalisation des objectifs critiques de la société, notamment en acceptant de travailler en dehors de sa zone d’expertise si nécessaire

Profil recherché

Qualifications et expérience

Essentielles

  • Bac+2/3 en Biotechnologie, Biologie Moléculaire, Chimie
  • 3 à 5 ans d’expérience en R&D (biologie moléculaire, diagnostic ou dans un domaine connexe)
  • Apprécie le travail sur systèmes robotisés et le développement technologique
  • Grande rigueur et qualité d’organisation
  • Dynamisme, réactivité
  • Aptitude à travailler au sein d’une équipe multidisciplinaire
  • Excellentes compétences en communication et relations interpersonnelles
  • Bonne maîtrise d’Excel

Souhaitables

  • Première expérience dans une société de biotechnologie et/ou dans un environnement de production/haut débit avec des systèmes d’automatisation
  • Bon niveau d’Anglais (équipe internationale)
  • Expérience dans les méthodes de biologie moléculaire, la purification ADN/ARN, la caractérisation des acides nucléiques et / ou la synthèse d’acides nucléiques

Informations diverses

  • Poste basé au Kremlin Bicêtre (94) – Ile de France – sortie métro ligne 7
  • Date d’embauche : Fin août-début septembre
  • Contrat : CDD/CDI en fonction du profil
  • Rémunération : à définir selon expérience

Déroulement des entretiens

  • Entretien téléphonique avec le manager
  • Entretiens dans nos locaux en présence du manager, des cofondateurs, des RH et du reste de l’équipe
  • Prise de références
  • Timing: 2 à 3 semaines
Apply now

The role

DNA Script is looking for an Enzyme Purification Research Assistant to strengthen the development and the production of its proprietary enzymes. You will join the enzyme production team composed of 8 scientists and be in charge of the protein production under the supervision of the enzyme DSP team leader. You will be responsible of the weekly batch purification of enzymes as well as the optimization of the purification process.

Responsibilities

  • Responsible of DSP reagents stocks
  • Perform all DSP steps required for protein purification (cell lysis, clarification, HPLC, concentration and aliquoting)
  • Participate in the process optimization for future industrialization
  • Validate enzyme batch quality through various internal quality control experiments
  • Be in charge of equipment maintenance (Homogenizer, HPLC, TFF, …)
  • Analyze results during purification process.
  • Techniques used: chromatography, SDS-PAGE, qPCR, …
  • Guarantee quality of the results in accordance with laboratory protocols and knowledge of GLP.

Qualifications and experience

  • Bachelor’s Degree in Biochemistry
  • At least 1 year of experience in laboratory
  • Experience with AKTA systems and UNICORN software
  • Highly motivated and proactive
  • Good biochemistry knowledge
  • Good organizational skills
  • Capable of working independently and with accuracy
  • Language: Good level in English

Miscellanous

  • Job located in Kremlin-Bicêtre (Paris area, 5 minutes from Porte d’Italie)
  • Start Date: as soon as possible
  • Full time, permanent position (CDI)
Recruitment process
  • Phone interview with manager
  • Day interview with manager, cofounders, HR and the team
  • References check
  • Timing: around 2-3 weeks
Apply now

Your Mission

DNA Script is looking for a talented scientist to take up a key role within the Applications team. He or she will be in charge of defining, developing and managing various projects to support the development of the company core technology. He or she will be responsible for interacting with internal and external partners to provide with thoroughly qualified oligonucleotides for their applications, to evaluate use and performances of oligos for various current applications and develop new application for the technology. This includes testing nucleic acid molecules in various set-ups and challenge with conventional chemistry synthetized oligos. This platform will play a central role for DNA Script by demonstrating the ability of Syntax and EDS technology to provide oligonucleotides that can be used for all current and future research applications.

To perform these tasks, the candidate will need to interact with many different teams, in particular the Bioinformatics team that will provide the oligonucleotide designs and perform analytics, the Synthesis platform that will produce the starting oligonucleotides and the NGS platform that will analyse the sequences. A technician hiring is planned in a near future to assist on projects.

We are seeking an individual who is well organized, proactive, detail-orientated, enjoys problem-solving, and able to work in a multi-disciplinary role.

Responsibilities

  • Define project outlines, experimental plans, perform experimentations and results analysis of a broad variety of assays based on EDS.
  • Develop and optimize methods based on nucleic acids manipulations.
  • Ensure efficient and reproducible day to day operations, provide high quality results, ensure high equipment uptime, manage team and resources (equipment, reagents, consumables),
  • Work collaboratively with groups across the company to set up appropriate projects.
  • Perform in-depth analysis of experimental data,
  • Engage in good laboratory/documentation practices, write Standard Operation Protocols (SOPs) and enforce their correct use,
  • Actively contribute towards critical company milestones, with a willingness to work outside immediate area of expertise where required.

Qualifications and experience

Essential:

  • Holds a PhD degree in the field of molecular biology/ biotechnology,
  • Minimum of 5 years’ experience in R&D after PhD graduation in managing challenging research projects in the field of cancer,
  • Experience of application development in an industrial environment,
  • Very comfortable/happy at the bench,
  • Highly experienced in molecular biology methods including methods of purification and characterisation of nucleic acids, PCR, qPCR, sequencing methods (Sanger, NGS), gene editing technologies (CRISPR…)
  • Excellent organisational, analytical, and systematic troubleshooting skills,
  • Excellent communication, reporting and interpersonal skills,
  • Positive experience of management of technicians or engineers,
  • Used to build, animated and managed scientific collaboration within an academic or private environment.
  • Highly motivated, pro-active, with a passion for developing tools and methods,
  • Ability to work independently and as part of a large multi-disciplinary team,
  • Dynamic with positive attitude willing to engage at a very high level,
  • Excellent English language level as well as at least an intermediate French language level.

Desirable:

  • Proven experience in the development of innovative processes.
  • Experience in nucleic acid handling (automated) and single cell technology.

Recruitment Process

Phone interview with manager
Day Interview at the office with manager, HR, cofounders and the team
References Check
Timing: 2-3 weeks

Apply now

The role

DNA Script is looking for a talented individual to take up a key role within the Applications team. He or she will be in charge of developing and managing the platform dedicated to produce nucleic acid assemblies based on the company’s enzymatic technology to manufacture de novo synthetic nucleic acids and novel assembly techniques. This platform will play a central role for DNA Script by demonstrating the ability of Syntax and EDS technology to provide oligonucleotides that can be used to produce any targeted synthetic gene.

The candidate will be in charge of implementing the full process of synthetic gene/nucleic acid assembly, from the reception of orders, oligonucleotide design, assembly production, sequencing analysis, QC and customer delivery. He or she will implement the specific assembly strategy defined by the R&D Assembly principal scientists in a given project. In addition, the candidate will be responsible of transferring the protocols developed by the R&D Assembly scientists in the Applications team and adapt them to the Assembly platform in a robust automated way.

To perform these tasks, the candidate will need to interact with many different teams, in particular the R&D Assembly scientists in the Applications team that will develop the assembly protocols and define the assembly strategy for a given project, the Bioinformatics team that will provide the oligonucleotide designs and perform analytics, the Synthesis platform that will produce the starting oligonucleotides and the NGS platform that will analyse the assembled sequences. He or she will be assisted by a technician.

We are seeking an individual who is well organized, proactive, detail-orientated, enjoys problem-solving, and is able to work in a multi-disciplinary role.

Responsibilities

  • Develop and manage an automated Assembly Platform: Ensure efficient and reproducible day to day operations, provide high quality results, ensure high equipment uptime, manage team and resources (equipment, reagents, consumables), 
  • Work collaboratively with groups across the company to set up appropriate projects
  • Perform in-depth analysis of experimental data, 
  • Effectively document and report on platform KPI, QC data and processes,
  • Engage in good laboratory/documentation practices, write Standard Operation Protocols (SOPs) and enforce their correct use,
  • Actively contribute towards critical company milestones, with a willingness to work outside immediate area of expertise where required.

Qualifications and experience

Essential

  • Process or biotechnology engineering, PhD or similar,
  • Minimum of five years’ experience in managing a service platform, preferentially in the field of molecular biology, 
  • Experience in molecular biology methods including PCR, restriction digestion, DNA/RNA purification, and nucleic acid characterisation and/ or in nucleic acid synthesis.
  • Experience in automation, liquid handlers, high throughput screening or analysis, 
  • Excellent knowledge of Excel and other Microsoft Tools, 
  • Excellent organisational, analytical, and systematic troubleshooting skills,
  • Excellent communication and interpersonal skills, 
  • Highly motivated, with a passion for developing tools and methods, 
  • Ability to work independently and as part of a large multi-disciplinary team,
  • Dynamic with positive attitude willing to engage at a very high level, 
  • Excellent English language level as well as at least an intermediate French language level.  

Desirable

  • Experience in following or implementing quality systems such as ISO 9001 or ISO 13485.
  • Experience in coding with Visual Basic Script (VBS), python or the like. 
  • Knowledge on gene assembly protocols

Recruitment process

1- Phone interview with manager

2- Day interview with manager, cofonders, HR and the team

3- References check

4- Timing: 2 to 3 weeks

The offer is available here: https://www.welcometothejungle.com/fr/companies/dna-script/jobs/biotechnology-platform-manager_le-kremlin-bicetre

Apply now

La mission 

DNA Script recherche un ingénieur en mécanique afin de participer à la conception (CAO), l’assemblage, les essais et la maintenance des prototypes qui seront nos futurs produits ou pour nos fabrications internes de réactifs. 

Les instruments automatisés utilisés par DNA Script mettent en œuvre les outils habituels de la robotique (motorisations, transmissions, guidages, capteurs, chauffage, électronique simple (arduino) et codage (Python, VB …) ainsi que des fonctions annexes mais essentielles de thermique, de mélange ou de micro-fluidique (dispense précise de liquide de quelques µl, valves, pompes…). 

Vous serez chargé de concevoir, de réparer ou de modifier tous nos automates en recherche et développement en leur ajoutant de nouvelles fonctions thermiques, optiques, fluidiques ou mécaniques et fonctions des demandes des chercheurs. 

Vous évoluerez au sein d’une équipe multidisciplinaire de chercheurs en biologie, d’ingénieurs en intégration système qui travailleront avec vous pour tester et améliorer vos réalisations de façon dynamique, rapide et efficace. Votre activité et vos résultats auront un impact direct au niveau du développement des futurs produits dans l’amélioration des produits actuels et des procédés de fabrication. Bien que très technique la mission demande une bonne compréhension des phénomènes physiques, fluidiques, thermiques, mis en jeu dans les instruments concernés.

Responsabilités 

  • Conception générale (mécanique, électronique, fluidique, thermique) d’instruments automatisés
  • Dimensionnement mécanique et électromécanique de pièces et de systèmes 
  • Réalisation de travaux d’assemblage et d’ajustage mécanique, câblage électrique, programmation simple électronique 
  • Test des assemblages, tests fonctionnels et contrôles des spécifications
  • Suivis des approvisionnements : commandes des pièces, suivi des sous-traitances, gestion des pièces de rechanges 

Expériences et compétences 

Requises 

  • Ecole d’ingénieur spécialité ou mécanique robotique :  ENSMM Besançon, INSA mécanique, SUPMECA, UTC Compiègne, UTT Troyes, IFMA Clermont….
  • 10 ans d’expérience dans la conception et réalisation de système automatisé pour le diagnostic, ou les sciences de la vie, ou machines spéciales 
  • Connaissance et pratique des circuits électroniques pour la commande des robots
  • Bon communiquant, compréhension des demandes non techniques et traduction en système
  • Travail d’équipe, bonne réactivité, débrouillard et créatif

Souhaitables 

  • Anglais courant 

Informations diverses 

  • Poste basé au Kremlin-Bicêtre (Paris)
  • Contrat : CDI
  • Début : ASAP

Apply now

Mission

DNA Script is looking for a R&D DSP Team Leader to strengthen the development and the production of its proprietary enzymes. You will join the enzyme production team composed of 8 scientists and be in charge of the purification activity under the supervision of the enzyme production group leader. You will be in charge of optimizing the purification process of different enzymes at different scale in order to increase the purification yield of those enzymes. You will have to collaborate with other teams, especially enzyme engineering team, to develop and improve DNA Script technology.

Responsibilities

  • Supervise DSP team composed of three members
  • Manage operational activities of purification area (production and optimization)
  • Identify and implement new downstream technology/instrumentation for continuous improvement of yield and throughput
  • Develop robust downstream process and support process transfer to external partners
  • Define strategy for the development, scale-up and optimization of the DSP process for multiple enzymes
  • Conduct experiments, interpreting results, drawing conclusions and recommending options for future experiments to achieve project goals
  • Support generation of WIs, SOPs, batch records and reports for internal tracking, technology transfer and development processes.
  • Recognize and resolve technical problems and evaluate options for complex experimental problems
  • Participate in routine maintenance and lab safety by following laboratory procedures and GLP

Qualifications and experiences

  • Hold a Master/Engineer degree or PhD preferably in biochemistry, protein purification, biotechnology or related fields
  • 8+ years of experience in proteins purification
  • Extensive theoretical knowledge and hands-on experience with chromatography techniques
  • Industrial experience in purification scale-up at pilot/commercial scale
  • Demonstrated management and leadership skills of scientific team
  • Demonstrated experience with managing multiple development projects in parallel
  • Excellent oral and written communication skills in English, good level of French is a plus
  • Proactive with excellent team spirit
  • Appreciate lab work in a dynamic and evolving environment

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area, 5 minutes from Porte d’Italie)
  • Start Date: as soon as possible
  • Contact: send your resume to jl@dnascript.com
Apply now