Transforming how molecular biology
translates to human health, personalized
medicine and synthetic biology.

our history
DNA Script believes in engineering biology to accelerate breakthroughs in life science and human health.
DNA Script was created to revolutionize DNA write with enzymes. Our core R&D efforts have produced innovations in enzyme engineering, surface and nucleotide chemistries, and instrumentation.  The integration of these innovations has resulted in SYNTAXTM, the world’s first benchtop DNA printer powered by enzymatic technology. With continued advancement and innovation, we believe DNA Script’s enzymatic DNA synthesis technology is poised to become the engine of genomics research as well as personalized medicine. 
our team

We’re science-driven thinkers, makers, dreamers and do-ers.

Founders
Thomas Ybert, PhD Co-Founder and CEO
Sylvain Gariel Co-Founder and COO
Xavier Godron Co-Founder and CTO
Meet the DNA Script team
See full team directory
Board Members
Thomas Ybert, PhD Co-Founder and CEO
Sylvain Gariel Co-Founder and COO
Joachim Rothe LSP
Nick Naclerio Illumina Ventures
Josko Bobanovic Sofinnova Partners
Philippe Peltier Kurma Partners
Paul MacEwan Independent Board Member
Heiner Dreismann Independent Board Member
Laurent Higueret Board Observer
Joey Mason Board Observer
our partners
lspvc-logo
illumina-ventures
sofinnova-logo
bpi-france-logo
m-ventures
kurma-partners-logo
idinvest-logo
easme-logo
institut-pasteur-logo
la-french-tech-logo
agoranov-logo
Casdin Capital Logo – Transparent – Large
Danaher
Agilent
values
We’re looking for great individuals who are committed to our company values.

Excellence

Take responsibility for your work. Aim to act, do and behave with the goal of reaching the unreachable.


Transparency

Give sincere, reliable and trustworthy information. Bring objective facts, no matter how they look.


Benevolence

Create a positive environment for everyone. Be supportive to the team, the company and your colleagues.

careers
We are synthesizing a technology revolution. Join us.
Product Development

The Role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a Senior Quality Assurance and Configuration Management Engineer to lead the software quality control and releases.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences. 

The position will be based in South San Francisco.

Responsibilities

  • Work with product management and marketing to capture and define customers requirements and influence overall product releases and testing direction to meet these specifications.
  • Lead a highly skilled QA team to design, develop, and enhance our Continuous Integration/Continuous Delivery system to support cloud-based and on-premise e-commerce application releases.
  • Work closely with QA engineers, UX/UI designers, software engineers, DevOps to develop e-commerce automation test system unit tests, integration tests, system tests, regression tests, performance tests, simulation tests and test metrics.
  • Strong technical leadership skills, people skills  with the ability to solve complex problems.
  • Constant quality improvement of code and infrastructure to achieve the best.

Requirements

  • A Bachelor’s Degree, or a Master’s Degree in software engineering or related field.
  • 5+ years of software quality control development in an e-commerce environment.
  • Prior experience developing tests with Selenium, WebDriverIO or equivalent.
  • Familiar with Continuous Integration / Continuous Delivery methodology.
  • Experience with integration test automation system with Jenkins or similar.
  • Experience developing test applications toward cloud-based applications (React/Node.js, and GraphQL, Apollo, Spring Boot, Postgres)
  • Experience developing web service tests for server-based micro-services applications (Java/Spring Boot)
  • Familiar with SQL and No-SQL databases
  • Experience integrating with third party solutions via web services API.

Ideal Candidate will have

  • Familiarity with enterprise NGS cloud-based systems, ideally Illumina’s BaseSpace / Design Studio
  • Track record of strong, team oriented, leadership abilities
  • The highest level of personal honesty, integrity and commitment; unquestionably walks the talk so others want to follow
  • Background in biological sciences, DNA applications, either from education or work experience.

Miscellaneous

  • Start date: Q3 2020
Apply now

Opportunity and Challenges 

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results. 

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.     

The Role

The Field Service & Support Manager/Sr. Manager is pivotal to the success of the Field Service and Technical Support teams at DNA Script, Inc. and accountable for delivering an exceptional Customer Experience. This individual will act as the primary point of contact for Service & Support  personnel and be the conduit between the field and internal teams. The individual will translate Service & Support strategy into impactful actionable plans for global training & enablement. Initially reporting to the Director of Systems Engineering, this position is responsible for the day-to-day success of the Service & Support team.

Responsibilities

  • Own and manage all Service & Support plans required to support system delivery & installation success at customer sites globally.
  • Develop, source, and deliver highly effective training programs to field service and technical support teams. 
  • Lead and coordinate the regional field service teams to assure rapid response to customer service & support inquiries.
  • Partner with Product Management, Product Development, Research and Development , and Software teams to design and develop internal and external training content and messaging.
  • Organize and host technical training classes for Service & Support teams to support new feature/product releases.
  • Drive the execution of product evaluation programs and act as the POC for service escalations.
  • On-board and mentor new Service & Support team members to ensure they are capable and successful in the field.
  • Collaborate with Product Management and Product Development to define and develop service product offerings & pricing strategy.
  • Represent Service & Support function in Project Core Teams and provide input in all New Product Development projects, including stage gate approval for service readiness.
  • Coordinate Spare Parts Inventory, timely dispatch of field personnel to perform maintenance, repair, and troubleshooting investigations.
  • Own lifecycle service management for products, follow the product continuum from development to launch, maturity, and end of lifecycle.
  • Manage all field communication, within service channels and end users, on product changes, updates, and conversions to ensure consistency across all regions.
  • Establish support processes and drive standardization to ensure exceptional customer experience across all field resources globally.
  • Actively collect, support & sustain engineering efforts as voice of customer for product improvement, design for service, and new product initiatives.
  • Dispatch field service teams in support of update programs and escalations; track issues, maintain KPI dashboard, etc.

Requirements

  • Bachelor’s degree in Science or Engineering field – e.g. Biochemistry, Biotechnology, Mechanical or Electrical Engineering .
  • 5+ years of experience in a similar position and/or service-related experience within the life science/biotech fields.
  • 3 – 5 years of experience leading Service & Support teams.
  • Exceptional written and verbal communication skills as well as analytical, project management and planning skills.
  • Excellent speaker with technical presentation skills to small groups and customers.
  • Customer service excellence mind-set is a MUST.
  • Experience with life science systems related service & support; including laboratory automation, analytical instrument, reagents, consumables, and software. 
  • Strong understanding of the New Product Introduction and New Product Development  processes and experience with new product design & development.
  • Ability to build and gain alignment among cross-functional teams to achieve results.
  • Experience with troubleshooting, problem-solving, and driving root cause analysis to resolution.
  • Ability to travel up to 25% domestically and internationally for global field training.

The Ideal Candidate will have

  • Start-up mind-set is strongly preferred.
  • Experience across the Product Support Lifecycle from launch to obsolescence.
  • Previous experience with managing/developing/leading teams remotely and across multiple regions/geographies strongly preferred.

Miscellaneous

  • Job located in South San Francisco
  • Requires frequent travel among DNA Script corporate offices and client sites throughout regions of the US and Europe.
  • Start date: Q3 2020

Apply now

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for an accomplished Field Service Engineer to support our partners and customers in their use and application of DNA Script’s commercial product. 

The individual will be responsible for leading complex technical inquiries in the field including troubleshooting and repairs, coordinating customer feedback and interactions, and representing user experiences within the company to aid development of next generation products. 

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The position will be based in Paris.

Responsibilities

  • Installs and optimizes hardware/software/network products and configurations at customer sites.
  • Diagnoses and resolves product performance problems.
  • Performs maintenance and repairs
  • Ensures customer satisfaction by advising customers on preventive maintenance and configurations, which may impact product performance.
  • Proactively responds to potential equipment issues to prevent unplanned interruption of customers’ business.
  • Delivers fully integrated solutions, which may include peripherals, communications, operating systems and applications software.
  • Trains other field engineers and customers in the company’s system products. 
  • Provides user-oriented and service-related  input to ongoing and new development projects.

Experience

  • Bachelors within the science field — e.g. biomedical engineering,  analytical biochemistry, biotechnology or similar is highly preferred
  • 4+ years of experience in a similar position and/or experience as an end-user of analytical instrumentation

Ideal Candidate will have

  • Experience or expertise with Laboratory Automation solutions (eg. pipetting robots, electronics and linear actuators) and systems involving reagents and consumables
  • Experience with troubleshooting and problem solving Customer service and solutions-oriented, with capability to precisely document issues, root cause analyses, troubleshooting experimentation and resolutions/repairs.
  • DNA Synthesis Experience, or Utilization of Synthetic Oligos in a biochemical application.
  • Excellent written and verbal communication skills
  • Ability to travel extensively including overnight travel as dictated by business needs

Miscellaneous

  • Remote Job based in Paris (France). Requires 75% travel to corporate offices and client sites throughout EU countries.
  • Start date: Q3 2020
Apply now

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results. 

DNA Script is actively searching for a Manufacturing & Procurement Technician who will be primarily responsible for the preparation of kits under good laboratory practices. This role will include inventory follow up, execute products preparation to build the kits with full traceability and interact with R&D teams to support customer demands. In addition, she/he will be responsible for procurement of all necessary items for kits production. 

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.     

The position will be US based, in the South San Francisco, California office. 

Responsibilities

  • Maintain inventory for laboratory and manufacturing operations @ SSF site
  • Maintain finished goods inventory, work in process and raw materials; recommend material orders as needed to maintain stocks for production
  • Monitor, qualify,  and maintain calibration of laboratory instrumentation used for manufacturing
  • Participate in planning activities pertaining to kit production
  • Use approved analysis techniques to characterize and ensure quality of synthesis reagents and products
  • Perform / assist with daily oligosynthesis operations and provide feedback to development
  • Perform reagent manufacturing, logistics planning and other tasks as necessary in a laboratory environment
  • Prepare buffers, solutions, and other kit components following approved protocols, including the use and safe handling of hazardous chemicals, data input and record keeping
  • Work with supply chain and logistics to optimize packaging and shipments, eliminating back orders
  • Assist in assembly and packaging of reagents and consumables for both domestic and international shipment
  • Procure and receive materials to support kit production and shipping
  • Execute tasks under approved SOPs, document production using batch records and contribute to improving overall quality in operations 
  • Contribute to development and execution of incoming inspection of received goods and stability tests
  • Work under the supervision of Product Development and Supply Chain management

Experience

  • Bachelors degree in Biology, Biochemistry, Chemistry or related field.
  • 1-3 years of relevant experience is preferred
  • Experience working in laboratory 
  • Experience working under GLP (Good Laboratory Practices) and following good documentation and compliance practices
  • Experience with laboratory safety procedures and documentation
  • Detail oriented and meticulous attention to detail 
  • Willingness to take/accept new responsibilities and able to work with minimal supervision.
  • Demonstrated ability to work in multidisciplinary teams

Miscellaneous

  • Job located in South San Francisco
  • Start date: Q4 2020
Apply now

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for an accomplished Field Service Engineer to support our partners and customers in their use and application of DNA Script’s commercial product. 

The individual will be responsible for leading complex technical inquiries in the field including troubleshooting and repairs, coordinating customer feedback and interactions, and representing user experiences within the company to aid development of next generation products. 

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The position will be US based, in the East Coast.

Responsibilities

  • Installs and optimizes hardware/software/network products and configurations at customer sites.
  • Diagnoses and resolves product performance problems.
  • Performs maintenance and repairs
  • Ensures customer satisfaction by advising customers on preventive maintenance and configurations, which may impact product performance.
  • Proactively responds to potential equipment issues to prevent unplanned interruption of customers’ business.
  • Delivers fully integrated solutions, which may include peripherals, communications, operating systems and applications software.
  • Trains other field engineers and customers in the company’s system products. 
  • Provides user-oriented and service-related  input to ongoing and new development projects.

Experience

  • Bachelors within the science field — e.g. biomedical engineering,  analytical biochemistry, biotechnology or similar is highly preferred
  • 4+ years of experience in a similar position and/or experience as an end-user of analytical instrumentation

Ideal Candidate will have

  • Experience or expertise with Laboratory Automation solutions (eg. pipetting robots, electronics and linear actuators) and systems involving reagents and consumables
  • Experience with troubleshooting and problem solving Customer service and solutions-oriented, with capability to precisely document issues, root cause analyses, troubleshooting experimentation and resolutions/repairs.
  • DNA Synthesis Experience, or Utilization of Synthetic Oligos in a biochemical application.
  • Excellent written and verbal communication skills
  • Ability to travel extensively including overnight travel as dictated by business needs

Miscellaneous

  • Remote Job based on the East Coast of USA. Requires 75% travel to corporate offices and client sites throughout Eastern region of US and other parts of North America.
  • Start date: Q3 2020
Apply now

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a motivated and efficient Laboratory Technician who will be focused on enabling and testing our DNA technology and the development of DNA Script’s commercial product. This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The position will be US based, in the South San Francisco, California office.

Responsibilities

  • Participate in the smooth operation of the laboratory. Order and receive materials, maintain a clean and organized lab environment, clean and maintain glassware, equipment as needed.
  • Generate key reagents for R&D that are robust and reproducible for both our current product and future generations of our platform
  • Precise documentation of experimental and QC processes to allow accurate traceability Characterize key reagents to establish performance criteria and specifications
  • Develop test methods and establish quality controls for new materials/processes involving polymers and polymer attachment to surfaces
  • Help to develop orthogonal analytical methods that can correlate with performance on our synthesis platform.
  • Follow established Laboratory Work Instructions and Standard Operating Procedures. 
  • Prepare and aliquot reagents for related experiments
  • Execute experimental plans, perform in-depth data analysis and present results and conclusions for internal review.
  • Work closely with team members to improve quality and performance of reagents.
  • Interface and assist with hardware engineering as needed to improve and extend DNA synthesis capabilities
  • Maintain a clean work environment including instruments and equipment and workspace
  • Conduct stability studies of reagents and buffers, following established protocols
  • Participate in the smooth operation of the laboratory. Order and receive materials, maintain a clean and organized lab environment, clean and maintain glassware, equipment as needed.
  • Generate key reagents for R&D that are robust and reproducible for both our current product and future generations of our platform
  • Precise documentation of experimental and QC processes to allow accurate traceability Characterize key reagents to establish performance criteria and specifications
  • Develop test methods and establish quality controls for new materials/processes involving polymers and polymer attachment to surfaces
  • Help to develop orthogonal analytical methods that can correlate with performance on our synthesis platform.
  • Follow established Laboratory Work Instructions and Standard Operating Procedures. 
  • Prepare and aliquot reagents for related experiments
  • Execute experimental plans, perform in-depth data analysis and present results and conclusions for internal review.
  • Work closely with team members to improve quality and performance of reagents.
  • Interface and assist with hardware engineering as needed to improve and extend DNA synthesis capabilities
  • Maintain a clean work environment including instruments and equipment and workspace
  • Conduct stability studies of reagents and buffers, following established protocols

Experience

  • Bachelors degree in Biology, Biochemistry, Chemistry or related field.
  • 1-3 years of experience is preferred

Ideal Candidate will have

  • Experience working in development or a GMP facility
  • Solid understanding of commercial product development
  • Experience in documenting procedures and writing SOPs is preferred
  • Hands-on experience in setting specifications, stability studies and guard band studies is preferred.
  • Detail oriented and meticulous attention to detail Proficiency with basic laboratory calculations, such as serial dilutions, molarity and micromolar calculations.
  • Willingness to take/accept new responsibilities and able to work with minimal supervision.
  • Knowledge of current and evolving trends in the NGS field
  • Demonstrated ability to trouble-shoot, and work in multidisciplinary teams.
  • Experience with operating instrumentation, such as NGS technologies, qPCR technologies, laboratory automation

Miscellaneous

  • Job located in South San Francisco
  • Start date: Q3 2020
Apply now

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a Software Instrumentation Engineer to champion software development and software/system integration efforts for complex mechatronic systems.

The individual will lead internal software functional development along with contributing in all stages of product development from prototype integration and optimization through commercialization.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences. 

The position will be based in Paris.

Responsibilities

  • Develop and integrate instrument control software from the prototype phase through release to manufacturing.
  • Develop software using C/C++ for use in life science laboratory automation and DNA Synthesis platforms and systems.
  • Participate in SW architecture development and risk mitigation activities, code reviews, system bring-up, integration, test, debug and verification activities
  • Work with other disciplines (EE, ME, SW) to define requirements, design, test, and debug embedded systems.
  • Interface with and collaborate with internal and external development partners, accelerating product development
  • Design, develop, test, deploy, maintain and improve software.
  • Manage individual project priorities, deadlines and deliverables.
  • Produce professional documentation and presentations.

Experience

  • A Bachelor’s in Computer Science, Computer Engineering or relevant technical field.
  • 2-3 years of relevant work experience.
  • Development experience within embedded systems/firmware design for automation systems.
  • Strong experience coding in C/C++.
  • Strong experience developing test methods based on Python
  • Ability to read electrical schematics and datasheets and to collaborate in design input and reviews.
  • Technical leadership skills, with the ability to lead small projects and/or in-discipline teams.
  • Experience in Biotechnology area is a significant plus
  • Experience in development of control software for laboratory automation systems is a significant plus

Ideal Candidate will have

  • Knowledge of Unix/Linux environments and kernel development.
  • Knowledge of State Machines
  • Knowledge of one or more of the following: Microcontrollers, device drivers, hardware bring-up, performance optimization, file systems, boot-loading, firmware.
  • Great with Python: In-depth knowledge of threading model, data structures, experience creating Python bindings in C and C++, and experience with regular expressions.
  • Use of source code management (SCM) tools (preferably GIT).
  • The highest level of personal honesty, integrity and commitment; unquestionably walks the talk so others want to follow.

Miscellaneous

  • Job located in Paris
  • Start date: Q3 2020
Apply now

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a Software Instrumentation Engineer to champion software development and software/system integration efforts for complex mechatronic systems.

The individual will lead internal software functional development along with contributing in all stages of product development from prototype integration and optimization through commercialization.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences. 

The position will be US based, in the South San Francisco, California office.

Responsibilities

  • Develop and integrate instrument control software from the prototype phase through release to manufacturing.
  • Develop software using C/C++ for use in life science laboratory automation and DNA Synthesis platforms and systems.
  • Participate in SW architecture development and risk mitigation activities, code reviews, system bring-up, integration, test, debug and verification activities
  • Work with other disciplines (EE, ME, SW) to define requirements, design, test, and debug embedded systems.
  • Interface with and collaborate with internal and external development partners, accelerating product development
  • Design, develop, test, deploy, maintain and improve software.
  • Manage individual project priorities, deadlines and deliverables.
  • Produce professional documentation and presentations.

Experience

  • A Bachelor’s in Computer Science, Computer Engineering or relevant technical field.
  • 2-3 years of relevant work experience.
  • Development experience within embedded systems/firmware design for automation systems.
  • Strong experience coding in C/C++.
  • Strong experience developing test methods based on Python
  • Ability to read electrical schematics and datasheets and to collaborate in design input and reviews.
  • Technical leadership skills, with the ability to lead small projects and/or in-discipline teams.
  • Experience in Biotechnology area is a significant plus
  • Experience in development of control software for laboratory automation systems is a significant plus

Ideal Candidate will have

  • Knowledge of Unix/Linux environments and kernel development.
  • Knowledge of State Machines
  • Knowledge of one or more of the following: Microcontrollers, device drivers, hardware bring-up, performance optimization, file systems, boot-loading, firmware.
  • Great with Python: In-depth knowledge of threading model, data structures, experience creating Python bindings in C and C++, and experience with regular expressions.
  • Use of source code management (SCM) tools (preferably GIT).
  • The highest level of personal honesty, integrity and commitment; unquestionably walks the talk so others want to follow.

Miscellaneous

  • Job located in South San Francisco
  • Start date: Q3 2020
Apply now
Research & Development

The Role

DNA Script is looking for a dynamic, talented individual to join the Nucleotide Chemistry team for an
internship in synthesis of modified nucleotides. The project consists in performing multistep synthesis
for different modified nucleotide targets. Those nucleotides will be then tested using our enzymatic
DNA synthesis technology to synthesize modified DNA for different types of application. The internship
will be supervised by a confirmed PhD in organic chemistry.

Qualification and Experience

Essential

  • Last year of engineering/ master degree in the field of organic chemistry
  • Good knowledge and practice in organic reaction, purification utilizing chromatography
  • techniques and analysis of organic molecules by TLC, NMR, HPLC, LC/MS
  • Ability to work as part of a large multi-disciplinary team
  • Good level of English
  • Excellent learning, organizational skills
  • Highly motivated candidate with passion for science

Desirable

  • Experience on nucleoside/nucleotide chemistry

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: As soon as possible
Apply now

The role

DNA Script is looking for a dynamic, talented individual to join the surface chemistry team for an internship in DNA probe synthesis.

The mission consists in developing methods and protocols for the preparation of DNA probes, including TaqMan probes, for qPCR assays. The intern will be in charge of modifying short DNA sequences (oligonucleotides) with a wide range of modifications (fluorophores, quenchers, biotin, etc.), via different coupling chemistries. He/she will also characterize the probes by UV/fluorescence spectroscopy, qPCR, and other analytical techniques. The internship will be supervised by the Team Leader a confirmed PhD in Chemistry.

Qualifications and experience

Essential

  • Last year of engineering school in the field of chemistry/biochemistry
  • Good knowledge in organic chemistry, in particular with biomolecules (DNA, proteins)
  • Good understanding of PCR/qPCR techniques
  • Good knowledge of UV and fluorescence spectroscopy
  • Excellent learning, organizational and analytical skills
  • Ability to work as part of a large multi-disciplinary team
  • Highly motivated, with a passion for new technologies

Desirable

  • Good level in French and/or English
  • Experience in bioconjugate chemistry
  • Experience in PCR/qPCR
  • Experience with solid supports (micro/nanoparticles)

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: As soon as possible
Apply now

Mission

DNA Script réalise la synthèse enzymatique de l’ADN de façon cyclique en ajoutant un nucléotide à chaque cycle. Ce procédé itératif nécessite de répéter les mêmes étapes ; l’élongation enzymatique, des lavages, puis la déprotection de la base ajoutée. Ce protocole doit donc être impérativement automatisé de manière robuste, fiable et précise pour obtenir une synthèse de haute qualité pour des fragments d’ADN de plusieurs centaines de nucléotides. DNA Script a donc développé une plateforme de synthèse utilisant des automates, chargée de fournir des fragments d’ADN à l’ensemble des collaborateurs de DNA Script.

Cette plateforme joue un rôle central pour DNA Script en évaluant d’une part les nouveaux réactifs (efficacité, stabilité…) pour les équipes de recherche et d’autre part en fournissant des oligonucléotides de qualité à l’équipe qui développe les applications ainsi qu’à nos collaborations externes. DNA Script recherche une personne talentueuse pour rejoindre l’équipe de la plateforme de synthèse.

Le candidat sera amené à interagir avec de nombreuses équipes différentes. Il/elle sera un support pour les activités des équipes de synthèse, effectuera les opérations quotidiennes sur la plateforme et réalisera les tests nécessaires à assurer la reproductibilité au jour le jour. Ce travail sera effectué en partie sur des systèmes robotiques de type « liquid handler ».

Nous recherchons une personne bien organisée, ayant le souci du détail, qui aime résoudre des problèmes et qui est capable de travailler dans un milieu multidisciplinaire. Le candidat devra avoir un esprit pratique et agile lui permettant de maîtriser les subtilités des systèmes robotiques. Il lui faudra comprendre à la fois la biologie moléculaire sous-jacente aux demandes des équipes et les impératifs de la plateforme afin de trouver le meilleur compromis.

Responsabilités

  • Préparer les différents tampons/réactifs nécessaires à la réalisation de tous les runs de synthèse et assurer leur QC
  • Réaliser les étapes de PSP (Post Synthesis Process) pour l’ensemble des runs de synthèse
  • Réaliser les opérations quotidiennes de manière efficace et reproductible, assurer une disponibilité élevée des équipements en réalisant des opérations de maintenance préventive (test de dispense, reproductibilité…)
  • Contribuer au développement et à la validation des protocoles de synthèse automatisés
  • Préparer et réaliser les runs de synthèse sur différents instruments
  • Participer aux étapes de manufacturing nécessaires à la préparation des premiers kits (préparation des réactifs, QC, aliquotage…)
  • Appliquer et contribuer au respect des bonnes pratiques de laboratoire
  • Contribuer activement à la réalisation des objectifs critiques de la société, notamment en acceptant de travailler en dehors de sa zone d’expertise si nécessaire

Qualifications et expérience

Essentielles

  • Bac+2 en Biotechnologie, Biologie Moléculaire, Chimie
  • 3 à 5 ans d’expérience en R&D (biologie moléculaire, diagnostic ou dans un domaine connexe)
  • Apprécie le travail sur automates et le développement technologique
  • Bonne maîtrise d’Excel
  • Grande rigueur et qualité d’organisation
  • Dynamisme, réactivité
  • Aptitude à travailler au sein d’une équipe multidisciplinaire
  • Excellentes compétences en communication et relations interpersonnelles

Souhaitables

  • Première expérience dans une société de biotechnologie et/ou dans un environnement de production/haut débit avec des systèmes d’automatisation
  • Bon niveau d’Anglais (équipe internationale)
  • Expérience dans les méthodes de biologie moléculaire, la purification ADN/ARN, la caractérisation des acides nucléiques et / ou la synthèse d’acides nucléiques

Informations diverses

  • Poste basé au Kremlin Bicêtre (94) – Ile de France – sortie métro ligne 7 
  • Date d’embauche : ASAP
  • Contrat : CDD 1 an
  • Rémunération : à définir selon expérience
Apply now

The role

DNA Script is looking for a talented molecular biologist, in a role that is central to the development of the company’s core technology.  The candidate will be responsible for managing a team of 3 to 5 scientists/engineers ensuring excellent quality work, good people and project management, organization and good communication with the Business development and marketing team. 

He or she will be in charge of interacting with external partners or future customers to provide them with thoroughly qualified oligos for their application. She or he will be developing new innovative application for our technology and produce application notes to open new markets in collaboration with marketing. These developments will have a direct impact on the R&D and product development process.

Responsibilities

  • Manage the Application Development Team, ensuring efficient organization, quality and thorough analysis of data, good communication and team spirit
  • Ensure good communication with partners and customers in particular in understanding their needs and providing data based on current synthesis and characterization methods hand in hand with Business Development and Marketing
  • Help with support to customers: understand their assays and results to help them troubleshoot if needed
  • Provide excellent quality documentation and reporting of experimental findings for internal and external use.
  • Provide technical presentation and Application notes for Marketing. 
  • Develop new applications based on the Business development or marketing feedback or on innovative idea taking advantage of unique aspects of our technology 
  • Engagement in good laboratory practices
  • Active contribution towards critical company milestones and strategy, with a willingness to work outside immediate area of expertise where required
  • Technology watch on new DNA uses and trends in market
  • Represent the company to the external world

Qualifications and experience

Essential

  • PhD in the field of molecular biology, biological process engineering, biotechnology or similar, 
  • Minimum of 10 years’ experience in R&D after PhD graduation (molecular biology, diagnostics, or a related field) with excellent laboratory skills and experience of common molecular biology methods such as nucleic acid isolation, quantification, PCR/qPCR, CRISPR, NGS library preparation, etc
  • Experience of application development in an industrial environment
  • Positive experience of management for at least 3 years after PhD graduation
  • Fluent in English with excellent writing and presenting skills
  • Ability to work efficiently and as part of a large multi-disciplinary team
  • Excellent communication and interpersonal skills
  • Excellent organisational, analytical, and systematic troubleshooting skills
  • Highly motivated, with a passion for new technologies 

Desirable

  • Some notion in French
  • Have some experience in field application support

Miscellanous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP
Apply now

The role

The Nucleotide Chemistry Group Leader will be in charge of the development, production and quality control of modified nucleotides, one of the key reagents in DNA Script’s technology.

You will play a key role at DNA Script, since we plan to enter the DNA market in the coming years and need to secure sourcing and pricing of these key reagents. Development of new modified nucleotides with additional functionalities is also crucial to broaden our technology applications.

Your roles will be to:
(i) Manage the Chemistry R&D team for the development of multiple types of modified nucleotides
(ii) Ensure the sourcing, production and quality of these nucleotides at large scale in adequation with the Company development and business plans

Responsibilities

  • Lead a team of 5 scientists (PhDs, engineers, technicians) to complete projects according to established timelines
  • Provide guidance to the team for developing new synthetic routes, establishing scalable and economical processes, optimizing process parameters and increasing internal production capabilities
  • Define strategy roadmap for the production of the modified nucleotide portfolio (internal/external) and the associated cost reduction
  • Lead the transfer of products from R&D to Contract Manufacturing Organizations (CMO)
  • Work with CMOs for large scale production, find new partners, negotiate mutually beneficial contracts and build strong beneficial partnerships
  • Author, review, and/or approve technology documents such as tech transfer documents, validation protocols, reports
  • Ensure the delivery of modified nucleotides and their quality at standards compatible with R&D needs and with upcoming DNA production operations

Qualifications and experience

Essential
  • Holds a Master or PhD degree in the field of Chemistry, Chemical Engineering or similar with a minimum of 8-10 years of industry experience required
  • Experience in R&D team and project management
  • Expertise in nucleic acid chemistry
  • Experience in sourcing and procurement
  • Experience in industrial process and scale-up
  • Experience in technology transfer with CMO
  • Excellent communication and interpersonal skills
  • Team player, efficient interaction with internal team members as well as external partners
  • Fluent English speaker
Desirable
  • Expertise in nucleoside and nucleotide chemistry
  • Experience with phosphoramidite chemistry

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP
Apply now

The role

DNA Script is looking for a bright, enthusiastic individual interested in taking up a permanent position to scoot, submit applications and track progress on externally funded R&D programs.

Today, DNA Script has been awarded 10+ millions of euros in various awards based on its enzymatic DNA synthesis technology:

  • In consortium with partners at 2 prestigious American universities to develop a technology for DNA digital data storage ($20m+ program)
  • On its own to scale-up the production of our reagents (H2020 SME Instruments 2.5m€ program)
  • Other subsidies in the fields of epigenetics, bioproduction and RNA from BPI France (4m€+ in total)

The Program Manager will be in charge of managing those projects, reporting, and launching new projects in similar fields.

In addition to that, he/she will help the CTO track progress and timelines for the R&D.

This is an ideal opportunity for a project manager with a scientific background and a passion for new technologies.

Responsibilities

  • Manage R&D programs
  • Lead interactions with governmental offices and consortium partners
  • Track progress, timelines and budget
  • Reporting to financiers
  • Assist legal team in identifying, and filing IP and participate in potential IP negotiations
  • Assist CTO in R&D organization and management

Qualifications and experience

Essential
  • Solid background in science. Ideally a PhD in Biology, Physics
  • 5yrs+ experience with excellent track record in project management
  • Good understanding of IP
  • Good presentation skills
  • Excellent writing skills
  • Excellent organization, communication and interpersonal skills
  • Ability to work as part of a large multi-disciplinary team
  • Professional level French and English
Desirable
  • Experience in molecular biology, protein engineering or electrochemistry
  • Good knowledge of DNA and its properties
  • Familiarity with French, European and/or US award system
  • Experience in consulting
  • Experience in project management IT tools
Apply now