Transforming how molecular biology
translates to human health, personalized
medicine and synthetic biology.

our history
DNA Script believes in engineering biology to accelerate breakthroughs in life science and human health.
DNA Script was created to revolutionize DNA write with enzymes. Our core R&D efforts have produced innovations in enzyme engineering, surface and nucleotide chemistries, and instrumentation.  The integration of these innovations has resulted in SYNTAXTM, the world’s first benchtop DNA printer powered by enzymatic technology. With continued advancement and innovation, we believe DNA Script’s enzymatic DNA synthesis technology is poised to become the engine of genomics research as well as personalized medicine. 
our team

We’re science-driven thinkers, makers, dreamers and do-ers.

Founders
Thomas Ybert, PhD Co-Founder and CEO
Sylvain Gariel Co-Founder and COO
Xavier Godron Co-Founder and CTO
Meet the DNA Script team
See full team directory
Board Members
Thomas Ybert, PhD Co-Founder and CEO
Sylvain Gariel Co-Founder and COO
Joachim Rothe LSP
Nick Naclerio Illumina Ventures
Josko Bobanovic Sofinnova Partners
Philippe Peltier Kurma Partners
Paul MacEwan Independent Board Member
Heiner Dreismann Independent Board Member
Laurent Higueret Board Observer
Joey Mason Board Observer
our partners
lspvc-logo
illumina-ventures
sofinnova-logo
bpi-france-logo
m-ventures
kurma-partners-logo
idinvest-logo
easme-logo
institut-pasteur-logo
la-french-tech-logo
agoranov-logo
values
We’re looking for great individuals who are committed to our company values.

Excellence

Take responsibility for your work. Aim to act, do and behave with the goal of reaching the unreachable.


Transparency

Give sincere, reliable and trustworthy information. Bring objective facts, no matter how they look.


Benevolence

Create a positive environment for everyone. Be supportive to the team, the company and your colleagues.

careers
We are synthesizing a technology revolution. Join us.
General & Administration

Mission

La mission d’ingénieur DevOps s’organise autour de deux axes principaux :

  1. La conception, le développement et la maintenance du système de gestion de l’information du laboratoire (LIMS) accompagnant SYNTAX™, le premier produit de DNA Script
  2. La gestion des systèmes d’information pour l’ensemble de la société

DNA Script développe SYNTAX™, le premier synthétiseur enzymatique d’acides nucléiques. Votre objectif sera de développer une plateforme en ligne permettant aux utilisateurs de SYNTAX™ d’accéder aux outils de conception spécifiques à ce produit (app store), de commander les réactifs et consommables nécessaires, de communiquer à DNA Script les informations requises pour la maintenance de l’instrument, et plus généralement de satisfaire leurs besoins présents et futurs.

Concernant la gestion des systèmes d’information de la société, vous aurez la charge de la maintenance du parc, de la mise en œuvre des bonnes pratiques – en particulier en matière de sécurité – ainsi que de l’architecture de gestion des données de la société.

Responsabilités

  • Structurer les sujets DevOps de la société
  • Concevoir, déployer et gérer des systèmes AWS scalables, disponibles en permanence et tolérants aux pannes
  • Concevoir, développer et implémenter toutes les technologies nécessaires à l’hébergement dans le cloud
  • Prendre la responsabilité de la gestion des incidents de production
  • Proposer et déployer une roadmap de système d’information permettant l’amélioration de la gestion et de la sécurité des données de l’entreprise
  • S’assurer de la conformité des systèmes d’informations aux législations en vigueur dans tous les pays dans laquelle la société opère (France et Etats-Unis pour l’instant)

Qualifications et expérience

Essentielles

  • Au moins 5 ans d’expérience professionnelle significative en informatique
  • Au moins 2 ans d’expérience en AwS
  • Etre capable de construire des pipelines sur Docker, npm, Java, Python, etc. avec divers outils DevOps sur EC2, Lambda, S3, Redbrick, etc.
  • Expérience sur les services de sécurité AWS suivants : VPC, Subnet, Elastic Network interface, Internet Gateway, Route table, NAT Gateway, Network ACL, Direct Connect, VPC Peering, VPN, EC2 
  • Expérience en automatisation CI/CD pour le DevOps : Jenkins, Chef, Docker, Ansibl, SaltStack, GitHub, GitLab, etc.
  • Expérience avec Docker et conteneurisation, Kubernetes, ECS, EKS
  • Expérience en scripting – Python, Batch, et Shell
  • Excellentes compétences en communication et bonne capacité à recueillir le besoin utilisateur
  • Résolution des problèmes et incidents liés aux services AWS
  • Sélection des services AWS pertinents
  • Grande qualité d’organisation et d’adaptation
  • Un souci du détail, une volonté de résoudre les problèmes et un esprit de service
  • Aptitude à travailler en en autonomie au sein d’une équipe multidisciplinaire
  • Anglais courant (équipe internationale)
  • Curiosité intellectuelle et affinité pour les sciences de la vie

Souhaitables

  • Certification AwS DevOps / Solution architect
  • Expérience en support IT

Informations diverses

  • Poste basé au Kremlin Bicêtre (94) – Ile de France – sortie métro ligne 7 
  • Date d’embauche : ASAP
  • Contrat : CDI à temps plein
  • Rémunération : à définir selon expérience

Contact

jd@dnascript.co

Apply now

As the Director of Manufacturing and Supply Chain you will be responsible for setting up and managing manufacturing processes both internally and externally, building and maintaining the supply chain, sourcing providers, negotiating prices in line with corporate targets and managing vendors. Ideally, you have a strong operational and production background in the industry of life science reagent kits.

Responsibilities
  • Develop, lead and execute manufacturing, assembly and shipping operations for kits of liquid reagents and consumables, including component sourcing, fill and finish, labelling, tracking and final shipping.
  • Develop, lead and execute supply chain management for liquid reagents, consumables and hardware from both internal production and external suppliers/partners, including both operational and administrative/legal topics
  • Develop, lead and execute procurement and purchasing strategies, including stock level optimization, in order to meet cost targets while ensuring continuity of supply
  • Set-up and manage manufacturing & supply chain team
  • Identify process bottlenecks and implement solutions in a timely manner
Qualifications and experience
Essential
  • Proven experience with manufacturing and handling of life science reagents and consumables, including fill & finish
  • Willingness to lead and execute assembly and logistic operations on the field
  • 5+ years of experience managing a large laboratory / manufacturing facility or extensive knowledge of Life Science business practices and financial management of Standard Costs and operating processes
  • Experience with Production Planning, Item Master Data (Bills of Material, Routing, Lot Costing Size, etc), and Capacity Planning
  • Proficient in MRP utilization for supply chain and inventory planning principles is required
  • Proven hands on experience with procurement and purchasing
  • Effective team player who possesses strong interpersonal and collaboration skills
  • Sense of urgency as to objectives and timelines, while maintaining flexibility to shifting priorities
  • Ability to prepare and deliver effective presentations. Strong organizational, analytical and reporting skills
  • Fluent English speaker and excellent communication skills
  • Attention to details
  • Bachelor’s Degree in Life Science, Business Management, Supply Chain Management, or related field
Desirable
  • Previous experience in a similar position in a biotech and/or life science company
  • APICS certification
  • Previous experience in recombinant protein production
  • Previous experience in nucleotide chemistry
Miscellanous
  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP

Apply now
Product Development

We are looking to assemble a team of best-in-class, innovative and passionate people. We want to gather their talents and
skills to achieve one goal: unlock the power of “DNA-write”. We offer the opportunity of joining a dynamic, international
and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to
change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the
promise of same-day results.

DNA Script is looking for a talented applications scientist to join our Product Development team. The candidate will be
responsible for the establishment, optimization and routine execution of NGS and PCR processes and applications
downstream of DNA synthesis, that qualify the performance of the platform in terms that meet the needs of prospective
customers.

The candidate will contribute to the design of application verification and validation tests, and she/he will interface with
marketing personnel and potential customers to define and refine acceptance criteria and methods. The position will
involve development and validation of new applications and automatable processes compatible with the company’s future
products.

The candidate will join a global team bringing together scientists from various fields of expertise. We are looking for a
person who is rigorous, well organized and detail-oriented. Pro-active, the candidate should be a problem-solver and
should have a strong ability to think “out of the box”, as well as willingness to suggest and to perform assays derived from
currently available methods.

The position will be based in the South San Francisco, California office.

Responsibilities

● Design and develop assays directed at qualifying DNA synthesis quality leveraging NGS and qPCR
● Contribute to/lead the design of synthesis controls which can be assayed within 24hours.
● Contribute to application verification and validation test design and acceptance tests.
● Participate in the smooth operation of the laboratory. Order and receive materials, maintain a clean and
organized lab environment, clean and maintain glassware, equipment as needed.
● Prepare buffers, solutions, reaction mixes, etc. following approved protocols.
● Collaborate with marketing/business development personnel to expand application portfolio and collaborations
with KOL’s.
● Contribute to experiments supporting the creation of application notes and marketing collateral.
● Interface and assist with hardware engineering as needed to improve and extend DNA synthesis capabilities
● Perform fluorescence labeling of DNA samples (end-labeling), order and maintain nucleotide solutions and
precursors
● Design primers and probes for qPCR studies and applications.
● Perform routine quality control tests of synthesized DNA: qPCR, spectrophotometric DNA quantitation, NGS.

Qualifications and experience
Essential

● A Bachelor’s in biology, biochemistry, or related field
● Minimum of 2 years’ experience working in a research laboratory or life science company, involving NGS and
qPCR
● Knowledge of molecular biological techniques for DNA library preparation for NGS
● Experience with reagent preparation & qualification and standard laboratory analysis equipment such as pH
meter, spectrophotometer, and electrophoresis.
● Strong documentation skills and ability to effectively communicate verbally and in writing, utilizing Word,
PowerPoint and Excel

Desirable

● Strong analytical mindset, detail oriented, and adept using Microsoft Excel or other tools to communicate and
present data.
● Knowledge and experience with using NGS and qPCR systems
● Past experience involving primer and probe design for qPCR
● Versatile and adaptable to new methods, technologies and approaches
● Relevant experience working in a GMP/GLP environment
● Excellent communications skills
● Proactive, solutions-focused

Miscellanous
  • Job located in South San Francisco; 279 East Grand Ave
  • Start date: Q1 2020

Contact: cdm@dnascript.co

Apply now
Research & Development

DNA Script is looking for a talented molecular biologist, in a role that is central to the development of the company’s core technology.  The candidate will be responsible for managing a team of 3 to 5 scientists/engineers ensuring excellent quality work, good people and project management, organization and good communication with the Business development and marketing team. 

He or she will be in charge of interacting with external partners or future customers to provide them with thoroughly qualified oligos for their application. She or he will be developing new innovative application for our technology and produce application notes to open new markets in collaboration with marketing. These developments will have a direct impact on the R&D and product development process.

Responsibilities

  • Manage the Application Development Team, ensuring efficient organization, quality and thorough analysis of data, good communication and team spirit
  • Ensure good communication with partners and customers in particular in understanding their needs and providing data based on current synthesis and characterization methods hand in hand with Business Development and Marketing
  • Help with support to customers: understand their assays and results to help them troubleshoot if needed
  • Provide excellent quality documentation and reporting of experimental findings for internal and external use.
  • Provide technical presentation and Application notes for Marketing. 
  • Develop new applications based on the Business development or marketing feedback or on innovative idea taking advantage of unique aspects of our technology 
  • Engagement in good laboratory practices
  • Active contribution towards critical company milestones and strategy, with a willingness to work outside immediate area of expertise where required
  • Technology watch on new DNA uses and trends in market
  • Represent the company to the external world

Qualifications and experience

Essential

  • PhD in the field of molecular biology, biological process engineering, biotechnology or similar, 
  • Minimum of 10 years’ experience in R&D (molecular biology, diagnostics, or a related field) with excellent laboratory skills and experience of common molecular biology methods such as nucleic acid isolation, quantification, PCR/qPCR, CRISPR, NGS library preparation, etc
  • Experience of application development in an industrial environment
  • Positive experience of management for at least 3 years 
  • Fluent in English with excellent writing and presenting skills
  • Ability to work efficiently and as part of a large multi-disciplinary team
  • Excellent communication and interpersonal skills
  • Excellent organisational, analytical, and systematic troubleshooting skills
  • Highly motivated, with a passion for new technologies 

Desirable

  • Some notion in French
  • Have some experience in field application support

Miscellanous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP

Contact

xg@dnascript.co et vb@dnascript.co

Apply now

DNA Script recherche une personne talentueuse pour rejoindre l’équipe de chimie des nucléotides en tant qu’ ingénieur en Chimie Analytique. Le candidat rapportera au responsable du groupe de chimie des nucléotides.

Responsabilités
  • Développer et implémenter de nouvelles méthodes pour la QC de différents nucléotides (en particulier des méthodes HPLC et LC-MS)
  • Développer et implémenter de nouvelles méthodes pour la synthèse d’intermédiaires (en particulier des méthodes HPLC et LC-MS)
  • Préparer les différentes solutions de nucléotides entrant dans le processus de DNA Script
  • Attribuer et enregistrer les numéros de lot
  • Effectuer un contrôle qualité de tous les nucléotides produits en interne ou en externe
  • Enregistrer les résultats des tests dans les documents adéquats (feuilles de contrôle de la qualité, cahier ou logiciel de laboratoire)
  • Effectuer des opérations de qualité de routine, y compris l’étalonnage / la maintenance de l’équipement
  • Rédaction de documents techniques, y compris des procédures d’utilisation normalisées (SOP)
  • Rapporter les données et analyses QC à votre responsable
  • Assurer la distribution de nucléotides à chaque équipe
  • Coordonner certains tests de QC avec d’autres équipes internes
  • Aider l’équipe de chimie des nucléotides (par exemple : purification des nucléotides et des impuretés)
Qualifications et expériences
  • De formation scientifique, ingénieur / chercheur chimiste ou biochimiste, niveau bac+5 minimum de préférence en chimie analytique.
  • Deux années d’expérience dans un laboratoire d’analyse ou d’environnement de contrôle qualité sont préférables.
  • Aptitude à écrire et à suivre les procédures et les directives
  • Capable de travailler de manière autonome et avec précision
  • Familier avec les analyses HPLC et LC-MS
  • Extrême rigueur et grande organisation
  • Méticuleux, souci du détail
  • Travail en équipe
  • Haut niveau de compétences techniques et de capacité de collaboration
  • Expérience dans le développement de méthodes HPLC est un plus
  • Maitrise de l’anglais
Informations diverses
  • Poste basé au Kremlin Bicêtre (94) – Ile de France – sortie métro ligne 7
  • Date d’embauche : ASAP
  • Contrat : CDI à temps plein

Apply now

The Nucleotide Chemistry Group Leader will be in charge of the development, production and quality control of modified nucleotides, one of the key reagents in DNA Script’s technology.

You will play a key role at DNA Script, since we plan to enter the DNA market in the coming years and need to secure sourcing and pricing of these key reagents. Development of new modified nucleotides with additional functionalities is also crucial to broaden our technology applications.

Your roles will be to:
(i) Manage the Chemistry R&D team for the development of multiple types of modified nucleotides
(ii) Ensure the sourcing, production and quality of these nucleotides at large scale in adequation with the Company development and business plans

Responsibilities
  • Lead a team of 5 scientists (PhDs, engineers, technicians) to complete projects according to established timelines
  • Provide guidance to the team for developing new synthetic routes, establishing scalable and economical processes, optimizing process parameters and increasing internal production capabilities
  • Define strategy roadmap for the production of the modified nucleotide portfolio (internal/external) and the associated cost reduction
  • Lead the transfer of products from R&D to Contract Manufacturing Organizations (CMO)
  • Work with CMOs for large scale production, find new partners, negotiate mutually beneficial contracts and build strong beneficial partnerships
  • Author, review, and/or approve technology documents such as tech transfer documents, validation protocols, reports
  • Ensure the delivery of modified nucleotides and their quality at standards compatible with R&D needs and with upcoming DNA production operations
Qualifications and experience
Essential
  • Holds a Master or PhD degree in the field of Chemistry, Chemical Engineering or similar with a minimum of 8-10 years of industry experience required
  • Experience in R&D team and project management
  • Expertise in nucleic acid chemistry
  • Experience in sourcing and procurement
  • Experience in industrial process and scale-up
  • Experience in technology transfer with CMO
  • Excellent communication and interpersonal skills
  • Team player, efficient interaction with internal team members as well as external partners
  • Fluent English speaker
Desirable
  • Expertise in nucleoside and nucleotide chemistry
  • Experience with phosphoramidite chemistry
Miscellanous
  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP

Apply now

DNA Script is looking for a talented candidate to strengthen its analytics platform which is an important part of the development team. Today, DNA Script’s analytical platform has two main missions:

  • Analyze DNA synthesis samples
  • Develop and continuously improve analytical techniques

The candidate will mainly be in charge of conducting methods development projects, on existing analytical equipment but also on future tools. With the help of the platform manager, the candidate will define project outlines, tests required and then lead experiments and result interpretation.

As the analytics platform is central to R&D, the candidate will have to interact with many different teams within the company, understand their needs and develop appropriate solutions.

The candidate will also be involved in all platform activities.

We are looking for a person who is rigorous, methodical, well organized, detail-oriented, problem-solver and capable of playing a cross-functional role within a multidisciplinary team.

Responsibilities
  • Develop analytical methods for R&D projects (sample preparation, methods of analysis, quantification method, etc.)
  • Develop and validate new LC-MS and capillary electrophoresis analysis methods
  • Qualify new analytical methods and equipment
  • Be accountable for the quality of analytical results, if necessary, help in data interpretation in collaboration with the applicants.
  • Assist the platform manager in the development of new characterization tests, in their implementation and in the data analysis.
  • Write analytical protocols and analytical development reports
  • Participate in the scientific and technical state of the art review
  • Participate in the organization of the analytical laboratory
  • Ensure communication with other teams
  • Manage several activities, their organization and planning while respecting the requested deadlines.
  • Participate in the maintenance and monitoring of analytical instruments and equipment
Qualifications and experience
Essential
  • Minimum Master of Science or equivalent Engineering degree: chemical engineer, biochemist or related, preferably in Analytical chemistry, bio-analyzes, biotechnology
  • Minimum two years in a diagnostic, biotech, agri-food or pharmaceutical industry, in the field of analytics in an R&D environment
  • Perfect knowledge of chromatographic techniques (HPLC, LC-MS) and associated software.
  • Excellent knowledge of the Office Pack
  • Excellent organizational and analytical skills
  • Excellent communication and interpersonal skills,
  • Highly motivated, passionate about developing tools and methods,
  • Ability to work independently and within a large multidisciplinary team,
  • Dynamic with a positive attitude willing to commit to a high level
  • Fluent English speaker
  • Good level in French
Desirable
  • Experience in the analysis of biomolecules, if possible, of DNA / oligonucleotides.
  • Experience with LIMS
  • Experience in an ISO 13485 accredited laboratory
Miscellanous
  • Job located in Kremlin-Bicêtre (Paris area)
  • Starting date: ASAP

Apply now

DNA Script is looking for a bright, enthusiastic individual interested in taking up a permanent position to scoot, submit applications and track progress on externally funded R&D programs.

Today, DNA Script has been awarded 10+ millions of euros in various awards based on its enzymatic DNA synthesis technology:

  • In consortium with partners at 2 prestigious American universities to develop a technology for DNA digital data storage ($20m+ program)
  • On its own to scale-up the production of our reagents (H2020 SME Instruments 2.5m€ program)
  • Other subsidies in the fields of epigenetics, bioproduction and RNA from BPI France (4m€+ in total)

The Program Manager will be in charge of managing those projects, reporting, and launching new projects in similar fields.

In addition to that, he/she will help the CTO track progress and timelines for the R&D.

This is an ideal opportunity for a project manager with a scientific background and a passion for new technologies.

Responsibilities
  • Manage R&D programs
  • Lead interactions with governmental offices and consortium partners
  • Track progress, timelines and budget
  • Reporting to financiers
  • Assist legal team in identifying, and filing IP and participate in potential IP negotiations
  • Assist CTO in R&D organization and management
Qualifications and experience
Essential
  • Solid background in science. Ideally a PhD in Biology, Physics
  • 5yrs+ experience with excellent track record in project management
  • Good understanding of IP
  • Good presentation skills
  • Excellent writing skills
  • Excellent organization, communication and interpersonal skills
  • Ability to work as part of a large multi-disciplinary team
  • Professional level French and English
Desirable
  • Experience in molecular biology, protein engineering or electrochemistry
  • Good knowledge of DNA and its properties
  • Familiarity with French, European and/or US award system
  • Experience in consulting
  • Experience in project management IT tools

Apply now