Transforming how molecular biology
translates to human health, personalized
medicine and synthetic biology.

our history
DNA Script believes in engineering biology to accelerate breakthroughs in life science and human health.
DNA Script was created to revolutionize DNA write with enzymes. Our core R&D efforts have produced innovations in enzyme engineering, surface and nucleotide chemistries, and instrumentation.  The integration of these innovations has resulted in SYNTAXTM, the world’s first benchtop DNA printer powered by enzymatic technology. With continued advancement and innovation, we believe DNA Script’s enzymatic DNA synthesis technology is poised to become the engine of genomics research as well as personalized medicine. 
our team

We’re science-driven thinkers, makers, dreamers and do-ers.

Founders
Thomas Ybert, PhD Co-Founder and CEO
Sylvain Gariel Co-Founder and COO
Xavier Godron Co-Founder and CTO
Meet the DNA Script team
See full team directory
Board Members
Thomas Ybert, PhD Co-Founder and CEO
Sylvain Gariel Co-Founder and COO
Joachim Rothe LSP
Nick Naclerio Illumina Ventures
Josko Bobanovic Sofinnova Partners
Philippe Peltier Kurma Partners
Paul MacEwan Independent Board Member
Heiner Dreismann Independent Board Member
Laurent Higueret Board Observer
Joey Mason Board Observer
our partners
lspvc-logo
illumina-ventures
sofinnova-logo
bpi-france-logo
m-ventures
kurma-partners-logo
idinvest-logo
easme-logo
institut-pasteur-logo
la-french-tech-logo
agoranov-logo
Casdin Capital Logo – Transparent – Large
Danaher
Agilent
values
We’re looking for great individuals who are committed to our company values.

Excellence

Take responsibility for your work. Aim to act, do and behave with the goal of reaching the unreachable.


Transparency

Give sincere, reliable and trustworthy information. Bring objective facts, no matter how they look.


Benevolence

Create a positive environment for everyone. Be supportive to the team, the company and your colleagues.

careers
We are synthesizing a technology revolution. Join us.
General & Administration

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionately impatient people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The Role

We are looking for an experienced Marketing Communications Manager/Sr. Manager who can own the integration of our brand and product messaging in communications across all media. This manager will have a strong focus on digital marketing to develop and drive a digital content roadmap that maximizes the reach of our products & services and delivers on our growth expectations. Ideally, this manager would have experience leading and transforming organizations to be more digitally focused. This is a critical role on the Commercial team that requires collaboration with team members in Marketing, Sales, Product Development and senior management. We’re looking for the leader who can ensure the elements of our brand are embodied in all of the different ways that customers will interact with our products, goods and services in all forms of communications.

Responsibilities

  • Lead and develop go-to-market plans for new products introductions by ensuring the consistency messaging and positioning, and coordinate execution across digital channels, sales training, and tradeshows.
  • Drive & execute marketing programs and campaigns to accelerate adoption of our platforms through strong partnerships with product management, applications, and sales.
  • Develop, budget, monitor, and evaluate the success of campaigns for optimization and continued effectiveness; determine ROI.
  • Formulate and drive digital strategy and content roadmap to transform and maximize reach, from ideation through execution and implementation.
  • Proactively identify, execute, and refresh content strategies to generate awareness, demand generation and improved customer experience and conversion.
  • Own and manage digital marketing assets; build a collateral portfolio for digital, virtual & print interactions.
  • Collaborate with Product Management and Applications to develop and produce educational materials for market outreach & expansion.
  • Own corporate messaging across all media channels.

Requirements

  • Have a passion for commercializing platforms that are at the leading-edge & accelerating innovation in life science.
  • Experienced in global product launches or specific programs and campaigns to support corporate & commercial strategy.
  • Have the drive and initiative to learn new skills and can demonstrate complete ownership of assigned marketing campaigns and programs.
  • Creative thinker and can help establish new frontiers in how we communicate with prospects, customers, investors, be unafraid to re-draw the box, etc.
  • Ability to convert complex technical concepts and product capabilities into crisp messages on benefits for the target audience in presentations & communication.
  • Effectiveness in building relationships with key stakeholders necessary for collaboration at all levels and influence without authority. Gain alignment and achieve results by power of influence alone.
  • BA/BS degree in marketing or equivalent preferably with background in Biological Sciences
  • 5+ years of marketing experience in a similar position within the life science industry.
  • Strong writing skills are required for this role, must demonstrate proven experience in writing digital content, technical writing, and/or copywriting.
  • Excellent communication skills with ability to present technical presentation in sales trainings, small groups and customers.
  • Ability to travel up to 25% domestic and international.

Preferably

  • Start-up mind-set is strongly preferred.
  • Experienced across the Marketing continuum.
  • Understanding of the new product introduction and product lifecycle management processes.
  • Account, vendor, or project management experience.

Miscellaneous

  • Job location: South San Francisco, US.
  • Requires travel among DNA Script corporate offices and client sites throughout US and Europe.
  • Start date: Q4 2020
Apply now

Opportunity and Challenges

We are looking to assemble a team of best-in-class, innovative and passionately impatient people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The Role

We are looking for an experienced Marketing Communications Manager/Sr. Manager who can own the integration of our brand and product messaging in communications across all media. This manager will have a strong focus on digital marketing to develop and drive a digital content roadmap that maximizes the reach of our products & services and delivers on our growth expectations. Ideally, this manager would have experience leading and transforming organizations to be more digitally focused. This is a critical role on the Commercial team that requires collaboration with team members in Marketing, Sales, Product Development and senior management. We’re looking for the leader who can ensure the elements of our brand are embodied in all of the different ways that customers will interact with our products, goods and services in all forms of communications.

Responsibilities

  • Lead and develop go-to-market plans for new products introductions by ensuring the consistency messaging and positioning, and coordinate execution across digital channels, sales training, and tradeshows.
  • Drive & execute marketing programs and campaigns to accelerate adoption of our platforms through strong partnerships with product management, applications, and sales.
  • Develop, budget, monitor, and evaluate the success of campaigns for optimization and continued effectiveness; determine ROI.
  • Formulate and drive digital strategy and content roadmap to transform and maximize reach, from ideation through execution and implementation.
  • Proactively identify, execute, and refresh content strategies to generate awareness, demand generation and improved customer experience and conversion.
  • Own and manage digital marketing assets; build a collateral portfolio for digital, virtual & print interactions.
  • Collaborate with Product Management and Applications to develop and produce educational materials for market outreach & expansion.
  • Own corporate messaging across all media channels.

Requirements

  • Have a passion for commercializing platforms that are at the leading-edge & accelerating innovation in life science.
  • Experienced in global product launches or specific programs and campaigns to support corporate & commercial strategy.
  • Have the drive and initiative to learn new skills and can demonstrate complete ownership of assigned marketing campaigns and programs.
  • Creative thinker and can help establish new frontiers in how we communicate with prospects, customers, investors, be unafraid to re-draw the box, etc.
  • Ability to convert complex technical concepts and product capabilities into crisp messages on benefits for the target audience in presentations & communication.
  • Effectiveness in building relationships with key stakeholders necessary for collaboration at all levels and influence without authority. Gain alignment and achieve results by power of influence alone.
  • BA/BS degree in marketing or equivalent preferably with background in Biological Sciences
  • 5+ years of marketing experience in a similar position within the life science industry.
  • Strong writing skills are required for this role, must demonstrate proven experience in writing digital content, technical writing, and/or copywriting.
  • Excellent communication skills with ability to present technical presentation in sales trainings, small groups and customers.
  • Ability to travel up to 25% domestic and international.

Preferably

  • Start-up mind-set is strongly preferred.
  • Experienced across the Marketing continuum.
  • Understanding of the new product introduction and product lifecycle management processes.
  • Account, vendor, or project management experience.

Miscellaneous

  • Job location: Paris, France.
  • Requires travel among DNA Script corporate offices and client sites throughout US and Europe.
  • Start date: Q4 2020

Apply now

The role

DNA Script is looking for a talented patent attorney to join the legal department, in a role that is central and critical to support the development of the company.  The candidate will be responsible for (i) patent preparation and prosecution ; (ii) patent committee and idea sourcing ; and (iii) related and competitor IP monitoring. writing and filling patent applications, managing existing patent portfolio and track office actions, animating patent committee and monitoring new ideas and findings, monitoring competitive landscape and IP.

Responsibilities

  • Drafting and filling patent applications
  • Managing existing patent and applications portfolio, maintaining internal docket and track office actions
  • Overseeing IP advisors and outside patent attorneys involved in patent prosecution
  • Managing inventorship and ensuring proof of ownership of the company invention via assignments
  • leading and organizing patent committees and new invention related processes
  • Monitoring new ideas and finding generated by the organization
  • Organizing and lead the interaction with innovating stakeholders in the Company to gather new ideas and findings
  • Track and follow operational team work related to patent filling and prosecution
  • Monitoring competitive landscape and IP
  • Conduct freedom-to-operate studies on regular basis or on ad-hoc requests
  • Conduct IP landscape analysis as requested by management or operational activities
  • Sensitize and train operational teams on importance and processes of IP
  • Manage internal communication on IP related activities
  • Provide legal help/support with general agreements and contract upon requests

Qualifications and experience

Essential

  • Has a Juris Doctorate or equivalent
  • Has an advanced degree in Molecular Biology, Bioengineering, Molecular Genetics, Synthetic Biology, Microbiology,  or a related biotechnology-relevant discipline or an advanced degree in Organic Chemistry, Nucleic Acid Chemistry or related biochemistry-relevant discipline.
  • Cumulate 3-5 years of total prior legal experience including time at a top-tier law firm and/or pharmaceutical or biotechnology industries
  • Proven track record in drafting and prosecuting biotechnology-related patent applications
  • Experience in working with research and development teams and environment
  • Experience in managing, organizing or taking part in IP committee or relevant processes
  • Possess working knowledge of transactional, commercial, and intellectual property law
  • Can handle large volume of work on a prioritized basis
  • Has exceptional attention for detail and accuracy abilities. As well as the ability to set a course that is optimal for the company in the context of both ambiguity and complicated and conflicting priorities.
  • Strong interactive skills and collaborative attitude to work effectively in a team environment
  • Has excellent organizational, project management and problem-solving skills with the ability to ensure to stay in budget and time while communicating clearly to the rest of the management team.
  • Has the highest levels of personal honesty, integrity and commitment.

Desirable

  • Experience in the field of DNA such as DNA synthesis or DNA sequencing
  • Start-up/small company experience
  • International and preferably US experience or work for a US firm

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP

Contact

vb@dnascript.co ; ty@dnascript.co

Apply now

The role

Lead the intellectual property function of the company, including counselling management on IP matters, overseeing and reviewing preparation and prosecution of patent applications, IP risk assessment and management, reviewing IP-related provisions of corporate contracts, and staff IP education.

Responsibilities

Intellectual property strategic guidance and counsel

  • Propose and implement IP strategy in line with Company’s business strategy and to ensure Company dominant IP position for the long term
  • Propose and manage in-licensing strategy to ensure Company dominant IP position for the long term
  • Provide high level, independent support for due diligence, strategic collaborations, licensing agreements and other business contracting needs
  • Provide opinion and recommendation to management on IP strategy and related activities

Patent strategy

  • Managing patents claims and filling strategy to unsure best strength, scope and position of patent portfolio to ensure long-term competitive advantage
  • Oversee and review of patent preparation and prosecution to maximize value of portfolio
  • Maintain positive relationships with external counsel and experts.
  • Recommend and help implement IP strategies for R&D project teams
  • Educate and advise senior management & scientists on important IP issues and advance IP/patent awareness.

Management and reporting of all intellectual property functions

  • Manage all IP related function and team
  • Build, manage and monitor IP functions and activities budget
  • Contribute to Company Board reporting and take part of Board meeting
  • Report and communicate internally IP activities on a regular basis

IP risk monitoring, litigation and associated strategy

  • Manage and support outside counsel in IP disputes, litigation, IPRs, PGRs and oppositions, including formulating appropriate IP litigation strategies
  • Develop a thorough understanding of DNA Script‘s current and planned business activities, programs, competitors, and markets and keep abreast of developing legal trends, laws and regulations.
  • Review publications, presentations, press releases and other materials for clearance.
  • Conduct or supervise freedom-to-operate, non-infringement, and competitive landscape analyses in key technology areas and product development

Qualifications and experience

Essential

  • JD, registered patent attorney
  • 12+ years of relevant IP experience in the life-science industry, including significant in-house experience.
  • An advanced degree in Molecular Biology, Bioengineering, Molecular Genetics, Synthetic Biology, Microbiology, or a related biotechnology-relevant discipline or an advanced degree in Organic Chemistry, Nucleic Acid Chemistry or related biochemistry-relevant discipline.
  • Direct experience in biologic patents and life-science tool product and product development
  • Experience in managing, organizing or taking part in IP committee or relevant processes
  • Possess working knowledge of transactional, commercial, and intellectual property law
  • Experience in Board reporting and Board meeting preparation and participation
  • Can handle large volume of work on a prioritized basis
  • Exceptional attention for detail and accuracy abilities.
  • Strong interactive skills and collaborative attitude to work effectively in a team environment
  • Excellent organizational, project management and problem-solving skills with the ability to ensure to stay in budget and time while communicating clearly to the rest of the management team.
  • Highest levels of personal honesty, integrity and commitment.

Desirable

  • Experience in the field of DNA technology, such as DNA synthesis or DNA sequencing
  • Start-up/small biotechnology company experience
  • International experience with or for non-US firms

Miscellaneous

  • Job located in South San Francisco (Bay area)
  • Start date: ASAP

Contact

vb@dnascript.co ; ty@dnascript.co

Apply now
Product Development

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for an accomplished Field Service Engineer to support our partners and customers in their use and application of DNA Script’s commercial product. 

The individual will be responsible for leading complex technical inquiries in the field including troubleshooting and repairs, coordinating customer feedback and interactions, and representing user experiences within the company to aid development of next generation products. 

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The position will be based in Paris.

Responsibilities

  • Installs and optimizes hardware/software/network products and configurations at customer sites.
  • Diagnoses and resolves product performance problems.
  • Performs maintenance and repairs
  • Ensures customer satisfaction by advising customers on preventive maintenance and configurations, which may impact product performance.
  • Proactively responds to potential equipment issues to prevent unplanned interruption of customers’ business.
  • Delivers fully integrated solutions, which may include peripherals, communications, operating systems and applications software.
  • Trains other field engineers and customers in the company’s system products. 
  • Provides user-oriented and service-related  input to ongoing and new development projects.

Experience

  • Bachelors within the science field — e.g. biomedical engineering,  analytical biochemistry, biotechnology or similar is highly preferred
  • 4+ years of experience in a similar position and/or experience as an end-user of analytical instrumentation

Ideal Candidate will have

  • Experience or expertise with Laboratory Automation solutions (eg. pipetting robots, electronics and linear actuators) and systems involving reagents and consumables
  • Experience with troubleshooting and problem solving Customer service and solutions-oriented, with capability to precisely document issues, root cause analyses, troubleshooting experimentation and resolutions/repairs.
  • DNA Synthesis Experience, or Utilization of Synthetic Oligos in a biochemical application.
  • Excellent written and verbal communication skills
  • Ability to travel extensively including overnight travel as dictated by business needs

Miscellaneous

  • Remote Job based in Paris (France). Requires 75% travel to corporate offices and client sites throughout EU countries.
  • Start date: Q3 2020
Apply now

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results. 

DNA Script is actively searching for a Manufacturing & Procurement Technician who will be primarily responsible for the preparation of kits under good laboratory practices. This role will include inventory follow up, execute products preparation to build the kits with full traceability and interact with R&D teams to support customer demands. In addition, she/he will be responsible for procurement of all necessary items for kits production. 

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.     

The position will be US based, in the South San Francisco, California office. 

Responsibilities

  • Maintain inventory for laboratory and manufacturing operations @ SSF site
  • Maintain finished goods inventory, work in process and raw materials; recommend material orders as needed to maintain stocks for production
  • Monitor, qualify,  and maintain calibration of laboratory instrumentation used for manufacturing
  • Participate in planning activities pertaining to kit production
  • Use approved analysis techniques to characterize and ensure quality of synthesis reagents and products
  • Perform / assist with daily oligosynthesis operations and provide feedback to development
  • Perform reagent manufacturing, logistics planning and other tasks as necessary in a laboratory environment
  • Prepare buffers, solutions, and other kit components following approved protocols, including the use and safe handling of hazardous chemicals, data input and record keeping
  • Work with supply chain and logistics to optimize packaging and shipments, eliminating back orders
  • Assist in assembly and packaging of reagents and consumables for both domestic and international shipment
  • Procure and receive materials to support kit production and shipping
  • Execute tasks under approved SOPs, document production using batch records and contribute to improving overall quality in operations 
  • Contribute to development and execution of incoming inspection of received goods and stability tests
  • Work under the supervision of Product Development and Supply Chain management

Experience

  • Bachelors degree in Biology, Biochemistry, Chemistry or related field.
  • 1-3 years of relevant experience is preferred
  • Experience working in laboratory 
  • Experience working under GLP (Good Laboratory Practices) and following good documentation and compliance practices
  • Experience with laboratory safety procedures and documentation
  • Detail oriented and meticulous attention to detail 
  • Willingness to take/accept new responsibilities and able to work with minimal supervision.
  • Demonstrated ability to work in multidisciplinary teams

Miscellaneous

  • Job located in South San Francisco
  • Start date: Q4 2020
Apply now

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a motivated and efficient Laboratory Technician who will be focused on enabling and testing our DNA technology and the development of DNA Script’s commercial product. This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences.    

The position will be US based, in the South San Francisco, California office.

Responsibilities

  • Participate in the smooth operation of the laboratory. Order and receive materials, maintain a clean and organized lab environment, clean and maintain glassware, equipment as needed.
  • Generate key reagents for R&D that are robust and reproducible for both our current product and future generations of our platform
  • Precise documentation of experimental and QC processes to allow accurate traceability Characterize key reagents to establish performance criteria and specifications
  • Develop test methods and establish quality controls for new materials/processes involving polymers and polymer attachment to surfaces
  • Help to develop orthogonal analytical methods that can correlate with performance on our synthesis platform.
  • Follow established Laboratory Work Instructions and Standard Operating Procedures. 
  • Prepare and aliquot reagents for related experiments
  • Execute experimental plans, perform in-depth data analysis and present results and conclusions for internal review.
  • Work closely with team members to improve quality and performance of reagents.
  • Interface and assist with hardware engineering as needed to improve and extend DNA synthesis capabilities
  • Maintain a clean work environment including instruments and equipment and workspace
  • Conduct stability studies of reagents and buffers, following established protocols
  • Participate in the smooth operation of the laboratory. Order and receive materials, maintain a clean and organized lab environment, clean and maintain glassware, equipment as needed.
  • Generate key reagents for R&D that are robust and reproducible for both our current product and future generations of our platform
  • Precise documentation of experimental and QC processes to allow accurate traceability Characterize key reagents to establish performance criteria and specifications
  • Develop test methods and establish quality controls for new materials/processes involving polymers and polymer attachment to surfaces
  • Help to develop orthogonal analytical methods that can correlate with performance on our synthesis platform.
  • Follow established Laboratory Work Instructions and Standard Operating Procedures. 
  • Prepare and aliquot reagents for related experiments
  • Execute experimental plans, perform in-depth data analysis and present results and conclusions for internal review.
  • Work closely with team members to improve quality and performance of reagents.
  • Interface and assist with hardware engineering as needed to improve and extend DNA synthesis capabilities
  • Maintain a clean work environment including instruments and equipment and workspace
  • Conduct stability studies of reagents and buffers, following established protocols

Experience

  • Bachelors degree in Biology, Biochemistry, Chemistry or related field.
  • 1-3 years of experience is preferred

Ideal Candidate will have

  • Experience working in development or a GMP facility
  • Solid understanding of commercial product development
  • Experience in documenting procedures and writing SOPs is preferred
  • Hands-on experience in setting specifications, stability studies and guard band studies is preferred.
  • Detail oriented and meticulous attention to detail Proficiency with basic laboratory calculations, such as serial dilutions, molarity and micromolar calculations.
  • Willingness to take/accept new responsibilities and able to work with minimal supervision.
  • Knowledge of current and evolving trends in the NGS field
  • Demonstrated ability to trouble-shoot, and work in multidisciplinary teams.
  • Experience with operating instrumentation, such as NGS technologies, qPCR technologies, laboratory automation

Miscellaneous

  • Job located in South San Francisco
  • Start date: Q3 2020
Apply now

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a Software Instrumentation Engineer to champion software development and software/system integration efforts for complex mechatronic systems.

The individual will lead internal software functional development along with contributing in all stages of product development from prototype integration and optimization through commercialization.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences. 

The position will be based in Paris.

Responsibilities

  • Develop and integrate instrument control software from the prototype phase through release to manufacturing.
  • Develop software using C/C++ for use in life science laboratory automation and DNA Synthesis platforms and systems.
  • Participate in SW architecture development and risk mitigation activities, code reviews, system bring-up, integration, test, debug and verification activities
  • Work with other disciplines (EE, ME, SW) to define requirements, design, test, and debug embedded systems.
  • Interface with and collaborate with internal and external development partners, accelerating product development
  • Design, develop, test, deploy, maintain and improve software.
  • Manage individual project priorities, deadlines and deliverables.
  • Produce professional documentation and presentations.

Experience

  • A Bachelor’s in Computer Science, Computer Engineering or relevant technical field.
  • 2-3 years of relevant work experience.
  • Development experience within embedded systems/firmware design for automation systems.
  • Strong experience coding in C/C++.
  • Strong experience developing test methods based on Python
  • Ability to read electrical schematics and datasheets and to collaborate in design input and reviews.
  • Technical leadership skills, with the ability to lead small projects and/or in-discipline teams.
  • Experience in Biotechnology area is a significant plus
  • Experience in development of control software for laboratory automation systems is a significant plus

Ideal Candidate will have

  • Knowledge of Unix/Linux environments and kernel development.
  • Knowledge of State Machines
  • Knowledge of one or more of the following: Microcontrollers, device drivers, hardware bring-up, performance optimization, file systems, boot-loading, firmware.
  • Great with Python: In-depth knowledge of threading model, data structures, experience creating Python bindings in C and C++, and experience with regular expressions.
  • Use of source code management (SCM) tools (preferably GIT).
  • The highest level of personal honesty, integrity and commitment; unquestionably walks the talk so others want to follow.

Miscellaneous

  • Job located in Paris
  • Start date: Q3 2020
Apply now

The role

We are looking to assemble a team of best-in-class, innovative and passionate people.  We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write”.  We offer the opportunity of joining a dynamic, international and highly skilled team in a pioneering startup. Our Next-Hour DNA Synthesis platforms not only have the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.

DNA Script is actively searching for a Software Instrumentation Engineer to champion software development and software/system integration efforts for complex mechatronic systems.

The individual will lead internal software functional development along with contributing in all stages of product development from prototype integration and optimization through commercialization.

This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences. 

The position will be US based, in the South San Francisco, California office.

Responsibilities

  • Develop and integrate instrument control software from the prototype phase through release to manufacturing.
  • Develop software using C/C++ for use in life science laboratory automation and DNA Synthesis platforms and systems.
  • Participate in SW architecture development and risk mitigation activities, code reviews, system bring-up, integration, test, debug and verification activities
  • Work with other disciplines (EE, ME, SW) to define requirements, design, test, and debug embedded systems.
  • Interface with and collaborate with internal and external development partners, accelerating product development
  • Design, develop, test, deploy, maintain and improve software.
  • Manage individual project priorities, deadlines and deliverables.
  • Produce professional documentation and presentations.

Experience

  • A Bachelor’s in Computer Science, Computer Engineering or relevant technical field.
  • 2-3 years of relevant work experience.
  • Development experience within embedded systems/firmware design for automation systems.
  • Strong experience coding in C/C++.
  • Strong experience developing test methods based on Python
  • Ability to read electrical schematics and datasheets and to collaborate in design input and reviews.
  • Technical leadership skills, with the ability to lead small projects and/or in-discipline teams.
  • Experience in Biotechnology area is a significant plus
  • Experience in development of control software for laboratory automation systems is a significant plus

Ideal Candidate will have

  • Knowledge of Unix/Linux environments and kernel development.
  • Knowledge of State Machines
  • Knowledge of one or more of the following: Microcontrollers, device drivers, hardware bring-up, performance optimization, file systems, boot-loading, firmware.
  • Great with Python: In-depth knowledge of threading model, data structures, experience creating Python bindings in C and C++, and experience with regular expressions.
  • Use of source code management (SCM) tools (preferably GIT).
  • The highest level of personal honesty, integrity and commitment; unquestionably walks the talk so others want to follow.

Miscellaneous

  • Job located in South San Francisco
  • Start date: Q3 2020
Apply now
Research & Development

The role

DNA Script is looking for a talented Bioinformatician to provide comprehensive bioinformatic support to its Application Development Team which is central to the development of the company’s core technology. Today, DNA Script’s Application Development Team main mission is to develop new innovative applications for our technology, involving the current use of sequence alignment, oligo design and Next Generation Sequencing (NGS) data, among others.

The candidate will be mainly in charge of leading the analysis and interpretation of high throughput sequencing datasets enabling the rapid evaluation of the applications under development. As such, the Bioinformatician will develop and apply bioinformatic methods and tools and perform tasks to help the Application team to interpret and prioritize their projects. In particular, the candidate will be in charge of developing:

  • Bioinformatic pipelines dedicated to the analyses of high throughput sequencing data
  • Tools for primer design

Bioinformatic analysis is central to the Application Development team therefore the candidate will need to interact with the different team members, understand their needs and develop the appropriate solutions.

We are looking for a person who is rigorous, methodical, well organized, detail-oriented, problem-solver and capable of playing a cross-functional role within a multidisciplinary team.

Qualifications and experience

Essential:

  • Master’s Degree/PhD in Bioinformatics or Senior Bioinformatician with 5+ years of significant computational experience related to bioinformatics work in academia, biotechnology, or other healthcare field involving next generation sequence data analysis
  • First-hand experience in NGS analysis and methods as well as the computing infrastructure and data management methods to support NGS
  • Perfect knowledge of:
    • Sequencing technologies and sound knowledge of the technical specificities inerrant to each of them (ie Illumina, PacBio, IonTorrent, Oxford Nanopore etc
    • Large dataset analysis in Python
    • Analyzing next generation sequencing data (DNA-seq, RNA-seq, etc.).
    • Building an NGS pipeline
    • Commonly used database and bioinformatics tools for NGS data analysis (e.g.) bedtools, SAMtools, IGV, ANNOVAR, Bowtie, GATK, ChimeraScan, UCSC Genome Browser, SoftGenetics, TopHat, etc.)
    • Proficiency in a scripting language (e.g. Python, 3.0) and Unix environments
  • Knowledge about molecular biology and genomics, ability to translate a biological question into a mathematical model/analysis method
  • Proven experience and success in a team-oriented environment
  • Feel comfortable in a fast-paced work environment
  • Excellent level of English and good level of French

Desirable:

  • First-hand experience at integrating publicly or commercially available genetic, genomic, and interaction datasets with novel experimental data to identify testable hypotheses
  • HTML/CSS, Javascript and SQL on NoSQL databases
  • Web framework (e.g. Django, etc)

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area, 5minutes from Porte D’Italie)
  • Start date: ASAP
Apply now

Mission

Dans le cadre de l’activité croissante de l’équipe production d’enzymes, composée de 6 personnes, nous recherchons un stagiaire (H/F) pour le pôle purification de l’équipe. Vous serez en charge du développement d’une méthode de purification alternative d’une polymérase pour la synthèse d’ADN, ceci dans le but d’améliorer sa pureté, sa qualité et ses coûts de production. Vous serez encadré/e par l’ingénieure en charge du projet qui vous accompagnera dans la création de protocoles, leur mise en œuvre, l’interprétation des résultats et leur présentation.

Responsabilités

  • Créer, appliquer et valider des protocoles de purification exploratoire.
  • Utiliser le système de chromatographie en phase liquide Äkta Pure 25L
  • Utiliser des outils de caractérisation physico-chimique des protéines (SDS-PAGE, TSA, …).
  • Réaliser les tests de contrôle qualité sur les différents lots de la polymérase purifiée.
  • Interpréter, mettre en page et présenter des résultats lors des réunions de l’équipe.
  • Être garant de la qualité des résultats dans le respect des protocoles du laboratoire et connaitre les BPL.
  • Participer à la vie de l’équipe purification : entretien des colonnes de purification, gestion des stocks et des réactifs, nettoyage hebdomadaire.

Qualifications et expériences

  • Esprit d’équipe et d’initiative
  • Apprécier le travail en laboratoire dans un environnement dynamique et évolutif
  • Bonnes capacités rédactionnelles et de synthèse
  • Anglais : écrit et parlé

Informations diverses

  • Poste basé au Kremlin-Bicêtre (94) – Ile de France – sortie Métro ligne 7
  • Date d’embauche : Janvier à Mars 2021
  • Contrat : 6 mois
  • Rémunération : 1200€ bruts

Apply now

The role

Become part of our enzyme engineering team and help us to evolve proprietary enzyme variants for DNA synthesis technology.

Responsibilities

•             Construct/express/screen the gene libraries

•             Purify proteins and plasmid DNA

•             Perform enzymatic activity tests

•             Support the team when needed

Qualifications and experience

Essential

•             Bachelors’ or Masters’ Degree in Biology, Biochemistry or Chemistry

•             ‘Hand on’ working experience in molecular biology or biochemistry lab

•             Familiarity with protein handling and purification

•             Familiarity with DNA handling and purification

•             Familiarity with protein structure and sequence analysis

•             Strong record keeping skills

•             Strong interpersonal skills

•             Good command of the English language

Desirable

•             Experience in directed evolution of proteins

Miscellaneous

•             Job located in Kremlin-Bicêtre (Paris area)

•             Start date: ASAP

Apply now

The role

DNA Script is looking for a talented chemist/biochemist to strengthen its Analytics platform which is an important part of the Development team. The role will be at the crossroad of surface chemistry and analytics providing the team with a novel vision and understanding of their process.

The candidate will be mainly in charge of:

  • Developing analytical methods to characterize modified oligonucleotides produced by enzymatic DNA synthesis
  • Study solid supports used for DNA synthesis and their role at different stages of the synthesis process by optical/confocal microscopy

We are looking for a person who is rigorous, methodical, well organized, detail-oriented, problem-solver and capable of playing a cross-functional role within a multidisciplinary team.

Responsibilities

  • Develop optical methods for the characterization of fluorescent/non-fluorescent oligonucleotides, including PCR/qPCR probes
  • Implement confocal microscopy as new characterization tool for solid supports used for DNA synthesis
  • Perform routine analysis of modified DNA and solid supports
  • Design and conduct experiments to support R&D projects
  • Help enrich analytical platform with instruments suitable for our R&D departments
  • Write analytical protocols and analytical development reports
  • Participate in the scientific and technical state of the art review

Qualifications and experience

Essential

  • Master 2 or Engineer in Chemistry/Biochemistry or any related field
  • Hands-on experience with optical characterization of biomolecules (UV-Vis, fluorescence, FRET, …)
  • At least 3 to 5 years of hands-on experience with optical microscopy / confocal microscopy
  • Ability to design, execute, interpret, and troubleshoot experiments
  • Excellent verbal and written communication, strong organizational and interpersonal skills
  • Highly motivated, passionate about developing tools and methods
  • Ability to work independently and within a large multidisciplinary team
  • Excellent level of English and good level of French

 Desirable

  • First significant experience in laboratory and biotechnology environment
  • Experience with fluorescent DNA probes (qPCR/TaqMan)
  • Familiar with image analysis software (ImageJ, …)

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP

Apply now

Mission

DNA Script is looking for a R&D Fermentation Engineer to reinforce the development and production of its proprietary enzymes. You will join the enzyme production team composed of 6 persons and support the fermentation activities under the supervision of the USP leader.  You will be in charge of optimizing the fermentation process of different enzymes in bioreactor from lab scale to pre-pilot scale in order to increase the production yield of those enzymes.  You will also manage strain optimization by using conventional molecular biology tools. You will participate to the production of enzyme batches in order to support R&D activities.

Responsibilities

  • Participate in the implementation of the optimization and production strategy
  • Conduct fermentations at different scales in bioreactors in autonomy
  • Perform optimizations in plates, flasks and bioreactors (500 ml to 30 L)
  • Ensure the quality and analytical monitoring of fermentations
  • Analyze, report and present the results
  • Suggest areas for improvement in order to increase the productivity of the enzymes produced
  • Manage strain optimization (construction, evaluation and storage of strain collection)
  • Conduct experiments by following laboratory procedures and GLP
  • Participate in the common tasks of the fermentation team: management of stocks and reagents (medium, strain, plasmid, petri dish), weekly cleaning

Qualifications and experiences

  • Holds a Master or an engineer degree in the field of biotechnology
  • At least 2-3 years of experience in fermentation
  • Knowledge in the implementation of experience plan (DOE)
  • Experience in the production of recombinant proteins and in protein expression screening in microtiter plate format
  • Experience in operating bioreactors in batch, fed batch and continuous culture mode
  • Experience in soluble/insoluble protein extraction as well as SDS-PAGE analysis
  • Skills in molecular biology (cloning, vector design) will be appreciated
  • Experience in colorimetric assays for the analysis of metabolites and substrates
  • Proactive with team spirit
  • Appreciate lab work in a dynamic and evolving environment
  • Good writing and synthesis skills
  • Good level of English
  • Knowledge in French

Miscellanous

  • Job located in Kremlin-Bicêtre (Paris area, 5 minutes from Porte d’Italie)
  • Start Date: Jan-Feb 2021
  • Contact: send your resume to ab@dnascript.com
Apply now

The role

DNA Script is looking for a talented Mass Spectrometry Specialist to strengthen its Analytics platform which is an important part of the Development team. Today, DNA Script’s analytical platform has two main missions:

  • A mission of service by analyzing all the synthesis samples and proprietary reagents of the R&D teams, mainly by LC-MS and capillary electrophoresis
  • A mission of development and continuous improvement of analytical techniques responding to the daily and specific need of all the R&D and more and more of the product development team members.
    The candidate will be mainly in charge of leading the Mass Spectrometry (LC-MS) instruments within the analytical platform, conducting analyses and method development with a new high-resolution mass spectrometer and developing analytical methods in support of R&D.
    As the analytics platform is central to R&D teams, the candidate will have to interact with many different teams, understand their needs and develop appropriate analytical solutions.
    We are looking for a person who is rigorous, methodical, well organized, detail-oriented, problem-solver and capable of playing a cross-functional role within a multidisciplinary team.

Responsibilities

  • Help evaluate, choose, install, and qualify a new LC-High-Resolution MS system
  • Develop analytical methods for R&D projects (sample preparation, methods of analysis, quantification method, etc.)
  • Conduct data analysis/interpretation to support R&D with analysis of nucleotides and oligonucleotides and provide comprehensive reports to non-Mass specialist
  • Ensure routine maintenance of the mass spectrometers including a newly acquired instrument (HR-MS), and existing instruments UPLC/single-quad system, as well as interfacing with vendors for instrument repair, when required
  • Be accountable of the analytical results quality, provide KPI and metrics to assess result quality and methods limitation
  • Work in close relationship with the synthesis platform in developing new high throughput analytical methods for oligonucleotides and contaminants characterization
  • Perform specific one-shot analysis for very specific demand providing deep understanding to certain specific questions
  • Communicate results by performing presentations, writing reports and SOPs
  • Perform regular state of the art studies on new innovative analytical methods, stay informed on new commercial products and upgrade

Qualifications and experience

Essential

  • PhD in Analytical Chemistry (Mass Spectrometry) or Senior Engineer with 10+ years of relevant experience
  • Demonstrated aptitude in biomolecule mass spectrometry, preferably oligonucleotides
  • Perfect knowledge of UPLC-MS and MS/MS techniques and associated software.
  • Ability to design, execute, interpret, and troubleshoot experiments
  • Excellent verbal and written communication
  • Strong organizational and interpersonal skills
  • Highly motivated, passionate about developing tools and methods
  • Ability to work independently and within a large multidisciplinary team
  • Excellent level of English and good level of French

Desirable

  • Experience in MS analysis of oligonucleotides
  • Experience with LIMS
  • Experience in an ISO 13485 accredited laboratory
  • Experience in Electrophoresis capillary or other analytical methods

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area, 5 minutes from Porte d’Italie)
  • Start date: ASAP
Apply now

The role

DNA Script is looking for a dynamic, talented individual to join the Enzyme Engineering team for an internship in developing an automated enzymatic oligonucleotide synthesis process. The internship will be in an international team of experienced chemists and biologist.
Your mission in this interdisciplinary project will be to:

  • conceive and organize experiments together with your supervisor
  • manipulate python scripts to control a liquid handling robot
  • prepare solutions of chemicals used by the robot to synthesize oligonucleotide
  • characterize oligonucleotide reaction products
  • prepare report and communicate results to supervisor and team.

Qualifications and experience

Essential

  • Last year of engineering/ master’s degree in biochemistry, chemistry or molecular biology
  • Good knowledge and skills in enzyme chemistry, oligonucleotide synthesis, solid phase synthesis,
  • Ability to understand/manipulate python scripts used to control liquid handling robot
  • Good biochemistry laboratory skills
  • Good organizational and reporting skills
  • Good communication skills and team player
  • Good level of English
  • Highly motivated

Desirable

  • Experience with high throughput screening
  • Good molecular biology skills

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: as soon as possible
  • Compensation: 1200€ / month
Apply now

The Role

DNA Script is looking for a dynamic, talented individual to join the Nucleotide Chemistry team for an
internship in synthesis of modified nucleotides. The project consists in performing multistep synthesis
for different modified nucleotide targets. Those nucleotides will be then tested using our enzymatic
DNA synthesis technology to synthesize modified DNA for different types of application. The internship
will be supervised by a confirmed PhD in organic chemistry.

Qualification and Experience

Essential

  • Last year of engineering/ master degree in the field of organic chemistry
  • Good knowledge and practice in organic reaction, purification utilizing chromatography
  • techniques and analysis of organic molecules by TLC, NMR, HPLC, LC/MS
  • Ability to work as part of a large multi-disciplinary team
  • Good level of English
  • Excellent learning, organizational skills
  • Highly motivated candidate with passion for science

Desirable

  • Experience on nucleoside/nucleotide chemistry

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: As soon as possible
Apply now

The role

DNA Script is looking for a dynamic, talented individual to join the surface chemistry team for an internship in DNA probe synthesis.

The mission consists in developing methods and protocols for the preparation of DNA probes, including TaqMan probes, for qPCR assays. The intern will be in charge of modifying short DNA sequences (oligonucleotides) with a wide range of modifications (fluorophores, quenchers, biotin, etc.), via different coupling chemistries. He/she will also characterize the probes by UV/fluorescence spectroscopy, qPCR, and other analytical techniques. The internship will be supervised by the Team Leader a confirmed PhD in Chemistry.

Qualifications and experience

Essential

  • Last year of engineering school in the field of chemistry/biochemistry
  • Good knowledge in organic chemistry, in particular with biomolecules (DNA, proteins)
  • Good understanding of PCR/qPCR techniques
  • Good knowledge of UV and fluorescence spectroscopy
  • Excellent learning, organizational and analytical skills
  • Ability to work as part of a large multi-disciplinary team
  • Highly motivated, with a passion for new technologies

Desirable

  • Good level in French and/or English
  • Experience in bioconjugate chemistry
  • Experience in PCR/qPCR
  • Experience with solid supports (micro/nanoparticles)

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: As soon as possible
Apply now

Mission

DNA Script réalise la synthèse enzymatique de l’ADN de façon cyclique en ajoutant un nucléotide à chaque cycle. Ce procédé itératif nécessite de répéter les mêmes étapes ; l’élongation enzymatique, des lavages, puis la déprotection de la base ajoutée. Ce protocole doit donc être impérativement automatisé de manière robuste, fiable et précise pour obtenir une synthèse de haute qualité pour des fragments d’ADN de plusieurs centaines de nucléotides. DNA Script a donc développé une plateforme de synthèse utilisant des automates, chargée de fournir des fragments d’ADN à l’ensemble des collaborateurs de DNA Script.

Cette plateforme joue un rôle central pour DNA Script en évaluant d’une part les nouveaux réactifs (efficacité, stabilité…) pour les équipes de recherche et d’autre part en fournissant des oligonucléotides de qualité à l’équipe qui développe les applications ainsi qu’à nos collaborations externes. DNA Script recherche une personne talentueuse pour rejoindre l’équipe de la plateforme de synthèse.

Le candidat sera amené à interagir avec de nombreuses équipes différentes. Il/elle sera un support pour les activités des équipes de synthèse, effectuera les opérations quotidiennes sur la plateforme et réalisera les tests nécessaires à assurer la reproductibilité au jour le jour. Ce travail sera effectué en partie sur des systèmes robotiques de type « liquid handler ».

Nous recherchons une personne bien organisée, ayant le souci du détail, qui aime résoudre des problèmes et qui est capable de travailler dans un milieu multidisciplinaire. Le candidat devra avoir un esprit pratique et agile lui permettant de maîtriser les subtilités des systèmes robotiques. Il lui faudra comprendre à la fois la biologie moléculaire sous-jacente aux demandes des équipes et les impératifs de la plateforme afin de trouver le meilleur compromis.

Responsabilités

  • Préparer les différents tampons/réactifs nécessaires à la réalisation de tous les runs de synthèse et assurer leur QC
  • Réaliser les étapes de PSP (Post Synthesis Process) pour l’ensemble des runs de synthèse
  • Réaliser les opérations quotidiennes de manière efficace et reproductible, assurer une disponibilité élevée des équipements en réalisant des opérations de maintenance préventive (test de dispense, reproductibilité…)
  • Contribuer au développement et à la validation des protocoles de synthèse automatisés
  • Préparer et réaliser les runs de synthèse sur différents instruments
  • Participer aux étapes de manufacturing nécessaires à la préparation des premiers kits (préparation des réactifs, QC, aliquotage…)
  • Appliquer et contribuer au respect des bonnes pratiques de laboratoire
  • Contribuer activement à la réalisation des objectifs critiques de la société, notamment en acceptant de travailler en dehors de sa zone d’expertise si nécessaire

Qualifications et expérience

Essentielles

  • Bac+2 en Biotechnologie, Biologie Moléculaire, Chimie
  • 3 à 5 ans d’expérience en R&D (biologie moléculaire, diagnostic ou dans un domaine connexe)
  • Apprécie le travail sur automates et le développement technologique
  • Bonne maîtrise d’Excel
  • Grande rigueur et qualité d’organisation
  • Dynamisme, réactivité
  • Aptitude à travailler au sein d’une équipe multidisciplinaire
  • Excellentes compétences en communication et relations interpersonnelles

Souhaitables

  • Première expérience dans une société de biotechnologie et/ou dans un environnement de production/haut débit avec des systèmes d’automatisation
  • Bon niveau d’Anglais (équipe internationale)
  • Expérience dans les méthodes de biologie moléculaire, la purification ADN/ARN, la caractérisation des acides nucléiques et / ou la synthèse d’acides nucléiques

Informations diverses

  • Poste basé au Kremlin Bicêtre (94) – Ile de France – sortie métro ligne 7 
  • Date d’embauche : ASAP
  • Contrat : CDD 1 an
  • Rémunération : à définir selon expérience
Apply now

The role

DNA Script is looking for a talented molecular biologist, in a role that is central to the development of the company’s core technology.  The candidate will be responsible for managing a team of 3 to 5 scientists/engineers ensuring excellent quality work, good people and project management, organization and good communication with the Business development and marketing team. 

He or she will be in charge of interacting with external partners or future customers to provide them with thoroughly qualified oligos for their application. She or he will be developing new innovative application for our technology and produce application notes to open new markets in collaboration with marketing. These developments will have a direct impact on the R&D and product development process.

Responsibilities

  • Manage the Application Development Team, ensuring efficient organization, quality and thorough analysis of data, good communication and team spirit
  • Ensure good communication with partners and customers in particular in understanding their needs and providing data based on current synthesis and characterization methods hand in hand with Business Development and Marketing
  • Help with support to customers: understand their assays and results to help them troubleshoot if needed
  • Provide excellent quality documentation and reporting of experimental findings for internal and external use.
  • Provide technical presentation and Application notes for Marketing. 
  • Develop new applications based on the Business development or marketing feedback or on innovative idea taking advantage of unique aspects of our technology 
  • Engagement in good laboratory practices
  • Active contribution towards critical company milestones and strategy, with a willingness to work outside immediate area of expertise where required
  • Technology watch on new DNA uses and trends in market
  • Represent the company to the external world

Qualifications and experience

Essential

  • PhD in the field of molecular biology, biological process engineering, biotechnology or similar, 
  • Minimum of 10 years’ experience in R&D after PhD graduation (molecular biology, diagnostics, or a related field) with excellent laboratory skills and experience of common molecular biology methods such as nucleic acid isolation, quantification, PCR/qPCR, CRISPR, NGS library preparation, etc
  • Experience of application development in an industrial environment
  • Positive experience of management for at least 3 years after PhD graduation
  • Fluent in English with excellent writing and presenting skills
  • Ability to work efficiently and as part of a large multi-disciplinary team
  • Excellent communication and interpersonal skills
  • Excellent organisational, analytical, and systematic troubleshooting skills
  • Highly motivated, with a passion for new technologies 

Desirable

  • Some notion in French
  • Have some experience in field application support

Miscellanous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP
Apply now

The role

The Nucleotide Chemistry Group Leader will be in charge of the development, production and quality control of modified nucleotides, one of the key reagents in DNA Script’s technology.

You will play a key role at DNA Script, since we plan to enter the DNA market in the coming years and need to secure sourcing and pricing of these key reagents. Development of new modified nucleotides with additional functionalities is also crucial to broaden our technology applications.

Your roles will be to:
(i) Manage the Chemistry R&D team for the development of multiple types of modified nucleotides
(ii) Ensure the sourcing, production and quality of these nucleotides at large scale in adequation with the Company development and business plans

Responsibilities

  • Lead a team of 5 scientists (PhDs, engineers, technicians) to complete projects according to established timelines
  • Provide guidance to the team for developing new synthetic routes, establishing scalable and economical processes, optimizing process parameters and increasing internal production capabilities
  • Define strategy roadmap for the production of the modified nucleotide portfolio (internal/external) and the associated cost reduction
  • Lead the transfer of products from R&D to Contract Manufacturing Organizations (CMO)
  • Work with CMOs for large scale production, find new partners, negotiate mutually beneficial contracts and build strong beneficial partnerships
  • Author, review, and/or approve technology documents such as tech transfer documents, validation protocols, reports
  • Ensure the delivery of modified nucleotides and their quality at standards compatible with R&D needs and with upcoming DNA production operations

Qualifications and experience

Essential
  • Holds a Master or PhD degree in the field of Chemistry, Chemical Engineering or similar with a minimum of 8-10 years of industry experience required
  • Experience in R&D team and project management
  • Expertise in nucleic acid chemistry
  • Experience in sourcing and procurement
  • Experience in industrial process and scale-up
  • Experience in technology transfer with CMO
  • Excellent communication and interpersonal skills
  • Team player, efficient interaction with internal team members as well as external partners
  • Fluent English speaker
Desirable
  • Expertise in nucleoside and nucleotide chemistry
  • Experience with phosphoramidite chemistry

Miscellaneous

  • Job located in Kremlin-Bicêtre (Paris area)
  • Start date: ASAP
Apply now

The role

DNA Script is looking for a bright, enthusiastic individual interested in taking up a permanent position to scoot, submit applications and track progress on externally funded R&D programs.

Today, DNA Script has been awarded 10+ millions of euros in various awards based on its enzymatic DNA synthesis technology:

  • In consortium with partners at 2 prestigious American universities to develop a technology for DNA digital data storage ($20m+ program)
  • On its own to scale-up the production of our reagents (H2020 SME Instruments 2.5m€ program)
  • Other subsidies in the fields of epigenetics, bioproduction and RNA from BPI France (4m€+ in total)

The Program Manager will be in charge of managing those projects, reporting, and launching new projects in similar fields.

In addition to that, he/she will help the CTO track progress and timelines for the R&D.

This is an ideal opportunity for a project manager with a scientific background and a passion for new technologies.

Responsibilities

  • Manage R&D programs
  • Lead interactions with governmental offices and consortium partners
  • Track progress, timelines and budget
  • Reporting to financiers
  • Assist legal team in identifying, and filing IP and participate in potential IP negotiations
  • Assist CTO in R&D organization and management

Qualifications and experience

Essential
  • Solid background in science. Ideally a PhD in Biology, Physics
  • 5yrs+ experience with excellent track record in project management
  • Good understanding of IP
  • Good presentation skills
  • Excellent writing skills
  • Excellent organization, communication and interpersonal skills
  • Ability to work as part of a large multi-disciplinary team
  • Professional level French and English
Desirable
  • Experience in molecular biology, protein engineering or electrochemistry
  • Good knowledge of DNA and its properties
  • Familiarity with French, European and/or US award system
  • Experience in consulting
  • Experience in project management IT tools
Apply now